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UniProtKB/Swiss-Prot entry Q9ZRA2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HGD_ARATH
Primary accession number Q9ZRA2
Secondary accession numbers Q8L9I0 Q9LDB8
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on April 27, 2001 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 58)
Name and origin of the protein
Protein name Homogentisate 1,2-dioxygenase
Synonyms EC 1.13.11.5
Homogentisic acid oxidase
Homogentisate oxygenase
Homogentisicase
Gene name
Name: HGO
OrderedLocusNames: At5g54080
ORFNames: MJP23.6
From
Arabidopsis thaliana (Mouse-ear cress) [TaxID: 3702] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Columbia;
Schmidt S.R., Werner E., Mueller C.R., Kress W.;
"Cloning and characterization of the homogentisate 1,2-dioxygenase gene in A. thaliana and C. elegans.";
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Schmidt S.R.;
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1093/dnares/7.1.31; PubMed=10718197 [NCBI, ExPASy, EBI, Israel, Japan]
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.;
"Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones.";
DNA Res. 7:31-63(2000).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
DOI=10.1126/science.1088305; PubMed=14593172 [NCBI, ExPASy, EBI, Israel, Japan]
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis genome.";
Science 302:842-846(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.;
"Full-length cDNA from Arabidopsis thaliana.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U80668; AAD00360.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF130845; AAF36499.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB018115; BAA97130.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY140075; AAM98216.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT010329; AAQ55280.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY088421; AAM65958.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_200219.1; -.
NP_851187.1; -.
UniGene At.23160
3D structure databases
HSSP Q93099; 1EYB. [HSSP ENTRY / PDB]
ModBase Q9ZRA2.
Organism-specific databases
TAIR At5g54080; -.
Gene expression databases
ArrayExpress Q9ZRA2; -.
GermOnline AT5G54080; Arabidopsis thaliana.
Family and domain databases
InterPro IPR005708; Homogentis_dOase.
Graphical view of domain structure.
PANTHER PTHR11056; Homogentis_dOase; 1.
Pfam PF04209; HgmA; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01015; hmgA; 1.
BLOCKS Q9ZRA2.
Genome annotation databases
GeneID 835494; -.
GenomeReviews BA000015_GR; AT5G54080.
KEGG ath:AT5G54080; -.
NMPDR fig|3702.1.peg.27312; -.
Other
ProtoNet Q9ZRA2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   461  461     Homogentisate 1,2-dioxygenase. PRO_0000220244
METAL   341   341        Iron (By similarity). 
METAL   347   347        Iron (By similarity). 
METAL   377   377        Iron (By similarity). 
CONFLICT   7     7        E -> K (in Ref. 5; AAM65958). 
CONFLICT   69    69        V -> I (in Ref. 5; AAM65958). 
CONFLICT   116   116        I -> T (in Ref. 5; AAM65958). 
CONFLICT   146   146        T -> K (in Ref. 5; AAM65958). 
CONFLICT   181   181        T -> S (in Ref. 5; AAM65958). 
CONFLICT   231   231        S -> P (in Ref. 5; AAM65958). 
CONFLICT   428   428        D -> E (in Ref. 1; AAD00360). 
CONFLICT   452   452        S -> P (in Ref. 5; AAM65958). 
Sequence information
Length: 461 AA [This is the length of the unprocessed precursor] Molecular weight: 51455 Da [This is the MW of the unprocessed precursor] CRC64: CD90DD9638014D31 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEEKKKELEE LKYQSGFGNH FSSEAIAGAL PLDQNSPLLC PYGLYAEQIS GTSFTSPRKL 

        70         80         90        100        110        120 
NQRSWLYRVK PSVTHEPFKP RVPAHKKLVS EFDASNSRTN PTQLRWRPED IPDSEIDFVD 

       130        140        150        160        170        180 
GLFTICGAGS SFLRHGFAIH MYVANTGMKD SAFCNADGDF LLVPQTGRLW IETECGRLLV 

       190        200        210        220        230        240 
TPGEIAVIPQ GFRFSIDLPD GKSRGYVAEI YGAHFQLPDL GPIGANGLAA SRDFLAPTAW 

       250        260        270        280        290        300 
FEDGLRPEYT IVQKFGGELF TAKQDFSPFN VVAWHGNYVP YKYDLKKFCP YNTVLLDHGD 

       310        320        330        340        350        360 
PSINTVLTAP TDKPGVALLD FVIFPPRWLV AEHTFRPPYY HRNCMSEFMG LIYGAYEAKA 

       370        380        390        400        410        420 
DGFLPGGASL HSCMTPHGPD TTTYEATIAR VNAMAPSKLT GTMAFMFESA LIPRVCHWAL 

       430        440        450        460 
ESPFLDHDYY QCWIGLKSHF SRISLDKTNV ESTEKEPGAS E 

Q9ZRA2 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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