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UniProtKB/Swiss-Prot entry Q9ZN36

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH_HELPJ
Primary accession number Q9ZN36
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on May 1, 1999 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 53)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP]
Synonyms IDH
EC 1.1.1.42
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
Gene name
Name: icd
OrderedLocusNames: jhp_0023
From
Helicobacter pylori J99 (Campylobacter pylori J99) [TaxID: 85963] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/16495; PubMed=9923682 [NCBI, ExPASy, EBI, Israel, Japan]
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D., Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori.";
Nature 397:176-180(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE001439; AAD05607.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E71982; E71982.
RefSeq NP_222745.1; -.
3D structure databases
HSSP P08200; 1PB1. [HSSP ENTRY / PDB]
ModBase Q9ZN36.
Enzyme and pathway databases
BioCyc HPYL85963:JHP0023-MON; -.
Family and domain databases
InterPro IPR004439; IsoCit_DHase_NADP_prok.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF1; NADP_IDH_prok; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00183; prok_nadp_idh; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q9ZN36.
Genome annotation databases
GeneID 889267; -.
GenomeReviews AE001439_GR; jhp_0023.
KEGG hpj:jhp0023; -.
NMPDR fig|85963.1.peg.23; -.
Phylogenomic databases
HOGENOM Q9ZN36; -.
Genome annotation databases
CMR Q9ZN36; jhp_0023.
Other
ProtoNet Q9ZN36.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   425  425     Isocitrate dehydrogenase [NADP]. PRO_0000083553
NP_BIND   348   354  7     NADP (By similarity). 
METAL   316   316        Magnesium or manganese (By similarity). 
BINDING   114   114        NADP (By similarity). 
BINDING   123   123        Substrate (By similarity). 
BINDING   125   125        Substrate (By similarity). 
BINDING   129   129        Substrate (By similarity). 
BINDING   139   139        Substrate (By similarity). 
BINDING   162   162        Substrate (By similarity). 
BINDING   361   361        NADP; via amide nitrogen and carbonyl oxygen (By similarity). 
BINDING   400   400        NADP (By similarity). 
BINDING   404   404        NADP (By similarity). 
SITE   169   169  1     Critical for catalysis (By similarity). 
SITE   239   239  1     Critical for catalysis (By similarity). 
MOD_RES   123   123        Phosphoserine (By similarity). 
Sequence information
Length: 425 AA [This is the length of the unprocessed precursor] Molecular weight: 47462 Da [This is the MW of the unprocessed precursor] CRC64: 356FE749774E053A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAYNPKILQK PKEGEEITIK DGKLHVPNYP IIPFIEGDGI GSDITPAMIK VVDSAVQKAY 

        70         80         90        100        110        120 
KGEKKIAWYE VFVGEKCYQK FKDHKELSPE EQWLLPDTIE AINHYKVSIK GPLTTPIGEG 

       130        140        150        160        170        180 
FRSLNVALRQ KMDLYVCLRP VRWYGSPSPV KEPQKVDMVI FRENSEDIYA GIEWQEGSAE 

       190        200        210        220        230        240 
AKKLIHFLQN ELKVEKIRFP ESSGVGIKPI SKEGTERLVR KAIEYAIDND KPSVTFVHKG 

       250        260        270        280        290        300 
NIMKYTEGAF MKWGYALAQK EFNAQVIDKG PWCSLKNPKT GKEIIIKDMI ADAFLQQILL 

       310        320        330        340        350        360 
RPSEYSVIAT MNLNGDYISD ALAAMVGGIG IAPGANLNDT VGMFEATHGT APKYAGLDKV 

       370        380        390        400        410        420 
NPGSIILSAE MMLRHMGWVE AADLIVSAME KAIKSKKVTY DFARLMDGAK EVKCSEFASV 


MIENM
Q9ZN36 in FASTA format

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