ID   P5CR_HELPJ              Reviewed;         257 AA.
AC   Q9ZK56;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-NOV-2008, entry version 51.
DE   RecName: Full=Pyrroline-5-carboxylate reductase;
DE            Short=P5C reductase;
DE            Short=P5CR;
DE            EC=1.5.1.2;
GN   Name=proC; OrderedLocusNames=jhp_1085;
OS   Helicobacter pylori J99 (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=99120557; PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G.,
RA   Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C.,
RA   Gibson R., Merberg D., Mills S.D., Jiang Q., Taylor D.E., Vovis G.F.,
RA   Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human
RT   gastric pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- CATALYTIC ACTIVITY: L-proline + NAD(P)(+) = 1-pyrroline-5-
CC       carboxylate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       proline from L-glutamate 5-semialdehyde: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase
CC       family.
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DR   EMBL; AE001439; AAD06667.1; -; Genomic_DNA.
DR   PIR; E71850; E71850.
DR   RefSeq; NP_223802.1; -.
DR   GeneID; 889724; -.
DR   GenomeReviews; AE001439_GR; jhp_1085.
DR   KEGG; hpj:jhp1085; -.
DR   NMPDR; fig|85963.1.peg.1080; -.
DR   HOGENOM; Q9ZK56; -.
DR   BioCyc; HPYL85963:JHP1085-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:InterPro.
DR   InterPro; IPR004455; NADP_OxRdtase_F420.
DR   InterPro; IPR000304; P5CR.
DR   PANTHER; PTHR11645; P5CR; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR   TIGRFAMs; TIGR00112; proC; 1.
DR   PROSITE; PS00521; P5CR; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP;
KW   Oxidoreductase; Proline biosynthesis.
FT   CHAIN         1    257       Pyrroline-5-carboxylate reductase.
FT                                /FTId=PRO_0000187292.
SQ   SEQUENCE   257 AA;  28203 MW;  9F219D8DB196F92A CRC64;
     MEILQFIGYG NMAQAILEGS HEILSKRFIL EITGRNPEKI APFLQEKNIQ AQIVPYKDAI
     DIHQKFVFLL FKPYNLKDFN YQGQAKSVLS ALAGVNFEAL SNAINSLHYL KCMPNIASKF
     ALSSTAVCEK SVAPSISEKA LNIIESFGNC VRVGNEEQVD SSVATNGSAL AFLSLVASSL
     KDAGIREGLN AKDSLELVKM SFKGFAKLLE KERPEMIIEQ ICTPKGATIE GLSVLEKKGV
     RGAFIKACHE SVKKMRL
//