NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1073/pnas.96.3.887; PubMed=9927663 [NCBI, ExPASy, EBI, Israel, Japan]
Hassouni M.E., Chambost J.P., Expert D., Van Gijsegem F., Barras F.;
"The minimal gene set member msrA, encoding peptide methionine sulfoxide reductase, is a virulence determinant of the plant pathogen Erwinia chrysanthemi.";
Proc. Natl. Acad. Sci. U.S.A. 96:887-892(1999).

Comments

FUNCTION: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide + H₂O = peptide-L-methionine (S)-S-oxide + thioredoxin.
CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H₂O = L-methionine (S)-S-oxide + thioredoxin.
SIMILARITY: Belongs to the msrA Met sulfoxide reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ012716; CAA10143.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P27110; 1FF3. [HSSP ENTRY / PDB]

SMR

Q9ZEQ8; 5-213.

ModBase

Q9ZEQ8.

Ontologies

GO:0008113;	Molecular function: peptide-methionine-(S)-S-oxide reductase activity (inferred from electronic annotation from HAMAP).
GO:0006464;	Biological process: protein modification process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01401; -; 1.
PBIL [Tree]

InterPro

IPR002569; MsrA.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.1060.10; MsrA; 1.

Pfam

PF01625; PMSR; 1.
Pfam graphical view of domain structure.

ProDom

PD003489; PMSR; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGR00401; msrA; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 213`	`213`	`Peptide methionine sulfoxide reductase msrA.`	`PRO_0000138549`
`ACT_SITE`	`53 53`		`By similarity.`

Sequence information

Length: 213 AA [This is the length of the unprocessed precursor]

Molecular weight: 23701 Da [This is the MW of the unprocessed precursor]

CRC64: 9EE0F02FE7428CB2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MIANFDKTQP IGQSDALPGR TTPMPVARLH VVNQHSMTHV PDHMEVAIFA MGCFWGVERL 

        70         80         90        100        110        120 
FWQQPGVYST ASGYCGGYTP NPTYREVCTG KTGHAEAVRV VFDPAVVSYP QLLQLFWENH 

       130        140        150        160        170        180 
NPAQGMRQGN DIGTQYRSAI YTLTTEQETA AKESYQRFQQ AMRDAGNDHD ITTEIQPAGP 

       190        200        210 
FYYAEDEHQQ YLHKNPDGYC GLGGIGVCLP PQG

Q9ZEQ8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools