ID   NUOA_RICPR              Reviewed;         123 AA.
AC   Q9ZDH1;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   04-NOV-2008, entry version 46.
DE   RecName: Full=NADH-quinone oxidoreductase subunit A;
DE            EC=1.6.99.5;
DE   AltName: Full=NADH dehydrogenase I subunit A;
DE   AltName: Full=NDH-1 subunit A;
GN   Name=nuoA; OrderedLocusNames=RP357;
OS   Rickettsia prowazekii.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=782;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   MEDLINE=99039499; PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O.,
RA   Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K.,
RA   Eriksson A.-S., Winkler H.H., Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
CC   -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-
CC       sulfur (Fe-S) centers, to quinones in the respiratory chain.
CC       Couples the redox reaction to proton translocation (for every two
CC       electrons transferred, four hydrogen ions are translocated across
CC       the cytoplasmic membrane), and thus conserves the redox energy in
CC       a proton gradient (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADH + quinone = NAD(+) + quinol.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the complex I subunit 3 family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AJ235271; CAA14817.1; -; Genomic_DNA.
DR   PIR; G71692; G71692.
DR   RefSeq; NP_220741.1; -.
DR   GeneID; 883383; -.
DR   GenomeReviews; AJ235269_GR; RP357.
DR   KEGG; rpr:RP357; -.
DR   HOGENOM; Q9ZDH1; -.
DR   BioCyc; RPRO272947:RP357-MON; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR   InterPro; IPR000440; Oxidored_q4.
DR   PANTHER; PTHR11058; Oxidored_q4; 1.
DR   Pfam; PF00507; Oxidored_q4; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Membrane; NAD; Oxidoreductase;
KW   Quinone; Transmembrane.
FT   CHAIN         1    123       NADH-quinone oxidoreductase subunit A.
FT                                /FTId=PRO_0000117876.
FT   TRANSMEM     11     31       Potential.
FT   TRANSMEM     68     88       Potential.
FT   TRANSMEM     93    113       Potential.
SQ   SEQUENCE   123 AA;  14342 MW;  39AFA4EEC7E04176 CRC64;
     MLQNSELLQE YLPIAIFFGI AVLLSVLIMI LPNLLSTKKY NKDKLEPYEC GFEPFSDARS
     KFDIRFYLVA ILFIIFDLEI AFLVPWAISL NTIGKMGFFS MMFFLFVLII GFIYEWTKGA
     LDW
//