ID   G6PD_RHIME              Reviewed;         491 AA.
AC   Q9Z3S2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2001, sequence version 2.
DT   25-NOV-2008, entry version 58.
DE   RecName: Full=Glucose-6-phosphate 1-dehydrogenase;
DE            Short=G6PD;
DE            EC=1.1.1.49;
GN   Name=zwf; OrderedLocusNames=R00704; ORFNames=SMc03070;
OS   Rhizobium meliloti (Sinorhizobium meliloti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=382;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=99328961; PubMed=10400573;
RA   Willis L.B., Walker G.C.;
RT   "A novel Sinorhizobium meliloti operon encodes an alpha-glucosidase
RT   and a periplasmic-binding-protein-dependent transport system for
RT   alpha-glucosides.";
RL   J. Bacteriol. 181:4176-4184(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   MEDLINE=21396507; PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D.,
RA   Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U.,
RA   Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont
RT   Sinorhizobium meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
CC   -!- CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP(+) = D-glucono-
CC       1,5-lactone 6-phosphate + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 1/3.
CC   -!- SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase
CC       family.
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DR   EMBL; AF045609; AAD12043.1; -; Genomic_DNA.
DR   EMBL; AL591688; CAC45276.1; -; Genomic_DNA.
DR   RefSeq; NP_384810.1; -.
DR   HSSP; P11413; 1QKI.
DR   GeneID; 1232343; -.
DR   GenomeReviews; AL591688_GR; R00704.
DR   KEGG; sme:SMc03070; -.
DR   NMPDR; fig|266834.1.peg.1998; -.
DR   HOGENOM; Q9Z3S2; -.
DR   BioCyc; SMEL266834:SMC03070-MON; -.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001282; Glc-6-P_DHase.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR23429; G6PDH; 1.
DR   Pfam; PF02781; G6PD_C; 1.
DR   Pfam; PF00479; G6PD_N; 1.
DR   PIRSF; PIRSF000110; G6PD; 1.
DR   PRINTS; PR00079; G6PDHDRGNASE.
DR   ProDom; PD001129; G6PD; 1.
DR   TIGRFAMs; TIGR00871; zwf; 1.
DR   PROSITE; PS00069; G6P_DEHYDROGENASE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP;
KW   Oxidoreductase.
FT   CHAIN         1    491       Glucose-6-phosphate 1-dehydrogenase.
FT                                /FTId=PRO_0000068132.
FT   ACT_SITE    242    242       Proton acceptor (By similarity).
FT   BINDING      19     19       NADP (By similarity).
FT   BINDING      51     51       NADP (By similarity).
FT   BINDING     180    180       Substrate (By similarity).
FT   BINDING     184    184       Substrate (By similarity).
FT   CONFLICT    401    401       R -> T (in Ref. 1; AAD12043).
SQ   SEQUENCE   491 AA;  55302 MW;  0D8B1AFD094E1775 CRC64;
     MSSQIIPVEP FDYVVFGGTG DLAERKLLPA LYHRQMEGQF TEPTRIIGAS RASLSHDEYR
     RFASDALKEH LKSGEFNEAE VEKFTSRLYY VSVDAKSEQG WDDLKKLLEE GKDRTRAFYL
     AVGPAIFSDI SEKIRDHKLI TRNTRIVVEK PIGRDLASAT ELNDTIGKVF REEQIFRIDH
     YLGKETVQNL MALRFANALY EPLWNSAHID HVQITVSEAV GLENRAGYYD KAGALRDMVQ
     NHILQLLCFV AMEAPTSMDA EAVRDEKLKV LRALKPITAS NVEQVTVRGQ YRAGASSGGP
     VKGYLEELEG GVSNTETFVA IKAEISNWRW AGVPFYLRTG KRMAGRMSEI VITFKQIPHS
     IFDQSAGRIS ANQLMIRLQP NEGVKQSLMI KDPGPGGMRL RNVPLDMSFA EAFAVRNADA
     YERLLLDVIR NNQTLFVRRD EVEAAWQWID PILKAWEATG QQVQGYTAGT WGPSQSIALI
     ERDGRTWNDA I
//