NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=10400573 [NCBI, ExPASy, EBI, Israel, Japan]
Willis L.B., Walker G.C.;
"A novel Sinorhizobium meliloti operon encodes an alpha-glucosidase and a periplasmic-binding-protein-dependent transport system for alpha-glucosides.";
J. Bacteriol. 181:4176-4184(1999).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=1021;
DOI=10.1073/pnas.161294398; PubMed=11481430 [NCBI, ExPASy, EBI, Israel, Japan]
Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.;
"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021.";
Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).

Comments

CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP⁺ = D-glucono-1,5-lactone 6-phosphate + NADPH.
PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3 .
SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF045609; AAD12043.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AL591688; CAC45276.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_384810.1; -.

3D structure databases

HSSP

P11413; 1QKI. [HSSP ENTRY / PDB]

ModBase

Q9Z3S2.

Enzyme and pathway databases

BioCyc

SMEL266834:SMC03070-MON; -.

Family and domain databases

InterPro

IPR001282; Glc-6-P_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR23429; G6PDH; 1.

Pfam

PF02781; G6PD_C; 1.
PF00479; G6PD_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000110; G6PD; 1.

PRINTS

PR00079; G6PDHDRGNASE.

ProDom

PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR00871; zwf; 1.

PROSITE

PS00069; G6P_DEHYDROGENASE; 1.

BLOCKS

Q9Z3S2.

Genome annotation databases

1232343; -.

AL591688_GR; R00704.

sme:SMc03070; -.

fig|266834.1.peg.1998; -.

Phylogenomic databases

HOGENOM

Q9Z3S2; -.

Genome annotation databases

CMR

Q9Z3S2; R00704.

Other

ProtoNet

Q9Z3S2.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 491`	`491`	`Glucose-6-phosphate 1-dehydrogenase.`	`PRO_0000068132`
`ACT_SITE`	`242 242`		`Proton acceptor (By similarity).`
`BINDING`	`19 19`		`NADP (By similarity).`
`BINDING`	`51 51`		`NADP (By similarity).`
`BINDING`	`180 180`		`Substrate (By similarity).`
`BINDING`	`184 184`		`Substrate (By similarity).`
`CONFLICT`	`401 401`		`R -> T (in Ref. 1; AAD12043).`

Sequence information

Length: 491 AA [This is the length of the unprocessed precursor]

Molecular weight: 55302 Da [This is the MW of the unprocessed precursor]

CRC64: 0D8B1AFD094E1775 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSSQIIPVEP FDYVVFGGTG DLAERKLLPA LYHRQMEGQF TEPTRIIGAS RASLSHDEYR 

        70         80         90        100        110        120 
RFASDALKEH LKSGEFNEAE VEKFTSRLYY VSVDAKSEQG WDDLKKLLEE GKDRTRAFYL 

       130        140        150        160        170        180 
AVGPAIFSDI SEKIRDHKLI TRNTRIVVEK PIGRDLASAT ELNDTIGKVF REEQIFRIDH 

       190        200        210        220        230        240 
YLGKETVQNL MALRFANALY EPLWNSAHID HVQITVSEAV GLENRAGYYD KAGALRDMVQ 

       250        260        270        280        290        300 
NHILQLLCFV AMEAPTSMDA EAVRDEKLKV LRALKPITAS NVEQVTVRGQ YRAGASSGGP 

       310        320        330        340        350        360 
VKGYLEELEG GVSNTETFVA IKAEISNWRW AGVPFYLRTG KRMAGRMSEI VITFKQIPHS 

       370        380        390        400        410        420 
IFDQSAGRIS ANQLMIRLQP NEGVKQSLMI KDPGPGGMRL RNVPLDMSFA EAFAVRNADA 

       430        440        450        460        470        480 
YERLLLDVIR NNQTLFVRRD EVEAAWQWID PILKAWEATG QQVQGYTAGT WGPSQSIALI 

       490 
ERDGRTWNDA I

Q9Z3S2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools