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UniProtKB/Swiss-Prot entry Q9Z2K8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDHC_MICOH
Primary accession number Q9Z2K8
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on May 1, 1999 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 44)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP] cytoplasmic
Synonyms IDH
EC 1.1.1.42
Cytosolic NADP-isocitrate dehydrogenase
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
Gene name
Name: IDH1
Synonyms: IDP2
From
Microtus ochrogaster (Prairie vole) [TaxID: 79684] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Cricetidae; Arvicolinae; Microtus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Liver;
PubMed=9866202 [NCBI, ExPASy, EBI, Israel, Japan]
Nekrutenko A., Hillis D.M., Patton J.C., Bradley R.D., Baker R.J.;
"Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family.";
Mol. Biol. Evol. 15:1674-1684(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF048832; AAD02925.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P33198; 1LWD. [HSSP ENTRY / PDB]
SMR Q9Z2K8; 1-414.
ModBase Q9Z2K8.
Family and domain databases
InterPro IPR004790; IsoCit_DHase_NADP-dep_euk.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11822; IDH_NADP_euk; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000108; IDH_NADP; 1.
TIGRFAMs TIGR00127; nadp_idh_euk; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q9Z2K8.
Phylogenomic databases
HOVERGEN Q9Z2K8; -.
Other
ProtoNet Q9Z2K8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   414  414     Isocitrate dehydrogenase [NADP] cytoplasmic. PRO_0000083577
NP_BIND   75    77  3     NADP (By similarity). 
NP_BIND   310   315  6     NADP (By similarity). 
REGION   94   100  7     Substrate binding (By similarity). 
METAL   252   252        Magnesium or manganese (By similarity). 
METAL   275   275        Magnesium or manganese (By similarity). 
BINDING   77    77        Substrate (By similarity). 
BINDING   82    82        NADP (By similarity). 
BINDING   109   109        Substrate (By similarity). 
BINDING   132   132        Substrate (By similarity). 
BINDING   260   260        NADP (By similarity). 
BINDING   328   328        NADP; via amide nitrogen and carbonyl oxygen (By similarity). 
SITE   139   139  1     Critical for catalysis (By similarity). 
SITE   212   212  1     Critical for catalysis (By similarity). 
Sequence information
Length: 414 AA [This is the length of the unprocessed precursor] Molecular weight: 46694 Da [This is the MW of the unprocessed precursor] CRC64: D8ECB6F9D9B87331 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSKKIHGGSV VEMQGDEMTR IIWELIKEKL ILPYVELDLH SYDLGIENRD ATNDQVTKDA 

        70         80         90        100        110        120 
AEAIKKYNVG VKCATITPDE KRVEEFKLKQ MWKSPNGTIR NILGGTVFRE AIICKNIPRL 

       130        140        150        160        170        180 
VTGWVKPIII GRHAYGDQYR ATDFVVPGPG KVEITYTPKD GSQKVTYLVH SFEEGGGVAM 

       190        200        210        220        230        240 
GMYNQDKSIE DFAHSSFQMA LSKGWPLYLS TKNTILKKYD GRFKDIFQEI YDKQYKSQFE 

       250        260        270        280        290        300 
AQKIWYEHRL IDDMVAQAMK SEGGFIWACK NYDGDVQSDS VAQGYGSLGM MTSVLICPDG 

       310        320        330        340        350        360 
KTVEAEAAHG TVTRHYRMHQ KGQETSTNPI ASIFAWSRGL AHRARLDNNT ELSFFAKALE 

       370        380        390        400        410 
EVCIETIEAG FMTKDLAACI KGLPNVQRSD YLNTFEFMDK LGENLKAKLA QAKL
Q9Z2K8 in FASTA format

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