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UniProtKB/Swiss-Prot entry Q9XEL8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH2_CAPAN
Primary accession number Q9XEL8
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on November 1, 1999 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 52)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
Synonyms HMG-CoA reductase 2
EC 1.1.1.34
Gene name
Name: HMGR2
From
Capsicum annuum (Bell pepper) [TaxID: 4072] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
Ha S.H., Kim J.B., Lee S.W., Hwang Y.S.;
"Pathogen-inducible HMGR2 gene from hot pepper.";
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF110383; AAD28179.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P04035; 1DQA. [HSSP ENTRY / PDB]
ModBase Q9XEL8.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
Graphical view of domain structure.
Gene3D G3DSA:3.90.770.10; HMG-CoA_red; 1.
PANTHER PTHR10572; HMG-CoA_red; 1.
Pfam PF00368; HMG-CoA_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; 1.
PS50065; HMG_COA_REDUCTASE_4; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9XEL8.
Other
ProtoNet Q9XEL8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Glycoprotein; Isoprene biosynthesis; Membrane; NADP; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   604  604     3-hydroxy-3-methylglutaryl-coenzyme A reductase 2. PRO_0000114436
TRANSMEM   47    67  21     Potential. 
TRANSMEM   91   111  21     Potential. 
REGION   112   188  77     Linker (By similarity). 
REGION   189   604  416     Catalytic (By similarity). 
ACT_SITE   283   283        Charge relay system (By similarity). 
ACT_SITE   415   415        Charge relay system (By similarity). 
ACT_SITE   491   491        Charge relay system (By similarity). 
ACT_SITE   589   589        Proton donor (By similarity). 
CARBOHYD   120   120        N-linked (GlcNAc...) (Potential). 
CARBOHYD   347   347        N-linked (GlcNAc...) (Potential). 
CARBOHYD   460   460        N-linked (GlcNAc...) (Potential). 
CARBOHYD   593   593        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 604 AA [This is the length of the unprocessed precursor] Molecular weight: 64881 Da [This is the MW of the unprocessed precursor] CRC64: CCCE77884BC5A362 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDVRRRSEEA VYSSKVFAAD EKPLKPHKQQ QEEDNTLLID ASDALPLPLY FTNGLFFTMF 

        70         80         90        100        110        120 
FSVMYFLLSR WREKIRNSTP LHVVTLSELG AIVSLIASVI YLLGFFGIGF VQTFVARGNN 

       130        140        150        160        170        180 
DSWDEEDEND EQFILEEDSR RGPCAAATTL GCAVPTPPAK HIAPIVPQQP AVSIAEKPAP 

       190        200        210        220        230        240 
LVTPAASEED EEIIKSVVQG KIPSYSLESK LGDCKRAASI RKEVLQRITG KSLEGLPLDG 

       250        260        270        280        290        300 
FNYESILGQC CEMTIGYVQI PVGIAGPLLL NGREYSVPMA TTEGCLVAST NRGCKAIYAS 

       310        320        330        340        350        360 
GGATSILLRD GMTRAPCVRF GTAKRAAELK FFVEDPINFE TLANVFNQSS RFARLQRIQC 

       370        380        390        400        410        420 
AIAGKNLHMR FVCSTGDAMG MNMVSKGVQN VLDYLQNEYA DMDVIGISAN FCSDKKPAAV 

       430        440        450        460        470        480 
NWIEGRGKSV VCEAIITEEV VKKVLKTEVA ALVELNMLKN LTGSALAGAL GGFNAHASNI 

       490        500        510        520        530        540 
VSAVYIATGQ DPAQNIESSH CITMMEAVND GKDLHISVTM PSIEVGTVGG GTQLASQSAC 

       550        560        570        580        590        600 
LNLLGVKGAN REAPGSNARL LATIVAGSVL AGELSLMSAI SAGQLVNSHM KYNRSTKDVT 


KASS
Q9XEL8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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