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UniProtKB/Swiss-Prot entry Q9V8M5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name 3HIDH_DROME
Primary accession number Q9V8M5
Secondary accession numbers Q0E926 Q86R98 Q9V8M6
Integrated into Swiss-Prot on January 24, 2001
Sequence was last modified on January 24, 2001 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 68)
Name and origin of the protein
Protein name Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Precursor]
Synonyms HIBADH
EC 1.1.1.31
Gene name
ORFNames: CG15093
From
Drosophila melanogaster (Fruit fly) [TaxID: 7227] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
DOI=10.1126/science.287.5461.2185; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan]
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[2]
GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan]
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
STRAIN=Berkeley;
TISSUE=Head;
Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE013599; AAF57638.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE013599; AAF57639.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY069057; AAL39202.2; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_611373.1; -.
NP_725824.1; -.
NP_725825.1; -.
UniGene Dm.21583
3D structure databases
ModBase Q9V8M5.
Protein-protein interaction databases
DIP DIP:22109N; -.
IntAct Q9V8M5; -.
Enzyme and pathway databases
BioCyc DMEL-XXX-02:DMEL-XXX-02-005425-MON; -.
DMEL-XXX-02:DMEL-XXX-02-005426-MON; -.
Organism-specific databases
FlyBase FBgn0034390; CG15093.
Gene expression databases
ArrayExpress Q9V8M5; -.
GermOnline CG15093; Drosophila melanogaster.
Ontologies
GO
GO:0005811; Cellular component: lipid particle (inferred from direct assay from FlyBase).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR002204; 3-OH-isobutyrate_DHase-rel_CS.
IPR015815; 3hydroxyacid_DHase/Rdtase.
IPR006183; 6-phosphogluconate_DHase.
IPR006115; 6PGDH_NAD-bd.
IPR013328; DHase_multihelical.
IPR011548; IsoBut3OH_DH.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
PANTHER PTHR22981; 3hydroxy_acid_DH; 1.
Pfam PF03446; NAD_binding_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00076; 6PGDHDRGNASE.
TIGRFAMs TIGR01692; HIBADH; 1.
PROSITE PS00895; 3_HYDROXYISOBUT_DH; 1.
BLOCKS Q9V8M5.
Genome annotation databases
Ensembl CG15093; Drosophila melanogaster. [Contig view]
GeneID 37166; -.
KEGG dme:Dmel_CG15093; -.
Phylogenomic databases
HOGENOM Q9V8M5; -.
Other
ProtoNet Q9V8M5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Complete proteome; Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    25  25     Mitochondrion (By similarity). 
CHAIN   26   324  299     Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial. PRO_0000007161
NP_BIND   29    58  30     NAD (By similarity). 
NP_BIND   92    93  2     NAD (By similarity). 
ACT_SITE   196   196        By similarity. 
BINDING   121   121        NAD; via amide nitrogen (By similarity). 
BINDING   271   271        NAD (By similarity). 
VAR_SEQ   95   227        NAIVDASYDEMTADGVNKDTIFIDSSTISPDLVKSLQKKI SAKGARFIDAPVSGGVPGAEQATLTFMVGGTEAEYNAVKA VLECMGKKITHCGVYGMGQAAKLCNNMMLAISMIGVSEAM NLAVRQGLDANVF -> KCRQGRPRVHGQEDHPLRRLWHGPGRQAVQQHDAGHLDDR CFGGHESGGAPGSRCQCLRRDHQLLHRTLLGLGDLQPCAR SLPQCPSQQGLRRRFLLGSDHQGSGSGLRSGQRFQLTHPA GISGAQGLPVAVR (in isoform C). VSP_001281
VAR_SEQ   228   324        Missing (in isoform C). VSP_001282
Sequence information
Length: 324 AA [This is the length of the unprocessed precursor] Molecular weight: 33883 Da [This is the MW of the unprocessed precursor] CRC64: A39B534753EAE83E [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSLRVMSPAM LNAWSQTLVR AMSTQGGAKN IGFVGLGNMG ANMASNLIKA GHKLHVFDIS 

        70         80         90        100        110        120 
KPACDGLAAK GATVYAKTSE LAKNSDFVIT MLPNNAIVDA SYDEMTADGV NKDTIFIDSS 

       130        140        150        160        170        180 
TISPDLVKSL QKKISAKGAR FIDAPVSGGV PGAEQATLTF MVGGTEAEYN AVKAVLECMG 

       190        200        210        220        230        240 
KKITHCGVYG MGQAAKLCNN MMLAISMIGV SEAMNLAVRQ GLDANVFAEI INSSTGRCWA 

       250        260        270        280        290        300 
SEIYNPVPGV CPSAPANRDY AGGFSSALIT KDLGLASGVA NASNSPIPLG SLAHKVYQSL 

       310        320 
CDKGLGNKDF SVVYDLMKKE KFSV 

Q9V8M5 in FASTA format

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