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UniProtKB/Swiss-Prot entry Q9URY5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FHP_SCHPO
Primary accession number Q9URY5
Secondary accession numbers None
Integrated into Swiss-Prot on March 20, 2007
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 50)
Name and origin of the protein
Protein name Flavohemoprotein
Synonyms EC 1.14.12.17
Flavohemoglobin
Hemoglobin-like protein
Nitric oxide dioxygenase
NO oxygenase
NOD
Gene name
ORFNames: SPAC869.02c
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
DOI=10.1038/nbt1222; PubMed=16823372 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.;
"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.";
Nat. Biotechnol. 24:841-847(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CU329670; CAB60012.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T39113; T39113.
RefSeq NP_595017.1; -.
3D structure databases
HSSP P04252; 4VHB. [HSSP ENTRY / PDB]
ModBase Q9URY5.
Organism-specific databases
GeneDB_Spombe SPAC869.02c; -.
Gene expression databases
ArrayExpress Q9URY5; -.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from direct assay from GeneDB_SPombe).
GO:0005739; Cellular component: mitochondrion (inferred by curator from GeneDB_SPombe).
GO:0005634; Cellular component: nucleus (inferred from direct assay from GeneDB_SPombe).
GO:0051410; Biological process: detoxification of nitrogen compound (inferred by curator from GeneDB_SPombe).
QuickGo view.
Family and domain databases
InterPro IPR012292; Globin.
IPR000971; Globin_subset.
IPR008333; OxRdtase_FAD-bd.
IPR001433; OxRdtase_FAD/NAD_bd.
Graphical view of domain structure.
Gene3D G3DSA:1.10.490.10; Globin_related; 1.
Pfam PF00970; FAD_binding_6; 1.
PF00042; Globin; 1.
PF00175; NAD_binding_1; 1.
Pfam graphical view of domain structure.
PROSITE PS51384; FAD_FR; 1.
PS01033; GLOBIN; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9URY5.
Genome annotation databases
GeneID 2542104; -.
KEGG spo:SPAC869.02c; -.
NMPDR fig|4896.1.peg.4987; -.
Other
ProtoNet Q9URY5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Detoxification; FAD; Flavoprotein; Heme; Iron; Metal-binding; NAD; NADP; Nucleus; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   427  427     Flavohemoprotein. PRO_0000280219
DOMAIN   177   285  109     FAD-binding FR-type. 
NP_BIND   232   235  4     FAD (By similarity). 
NP_BIND   301   306  6     NADP (By similarity). 
NP_BIND   421   424  4     FAD (By similarity). 
REGION   28   170  143     Globin. 
REGION   176   427  252     Reductase. 
REGION   290   427  138     NAD or NADP-binding. 
ACT_SITE   124   124        Charge relay system (By similarity). 
ACT_SITE   167   167        Charge relay system (By similarity). 
METAL   114   114        Iron (heme proximal ligand) (By similarity). 
BINDING   216   216        FAD (By similarity). 
SITE   58    58  1     Involved in heme-bound ligand stabilization and O-O bond activation (By similarity). 
SITE   113   113  1     Influences the redox potential of the prosthetic heme and FAD groups (By similarity). 
SITE   420   420  1     Influences the redox potential of the prosthetic heme and FAD groups (By similarity). 
Sequence information
Length: 427 AA [This is the length of the unprocessed precursor] Molecular weight: 48459 Da [This is the MW of the unprocessed precursor] CRC64: 869E5D4578F309D6 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSSVEVNREN ADVANTNRQA NLAEGYEIKE LNESQKQYIR SSIPILESSG VNLTKAFYQK 

        70         80         90        100        110        120 
MLGNYPEVLP YFNKAHQISL SQPRILAFAL LNYAKNIDDL TSLSAFMDQI VVKHVGLQIK 

       130        140        150        160        170        180 
AEHYPIVGHC LLSTMQELLP SDVATPAFLE AWTTAYGNLA KILIDSEKKV YQSQPWNGFV 

       190        200        210        220        230        240 
EFKVTELINE SSDVKSVYLG PKDPAFRISH AHPGQYVSVL WEIPGLSHKT LREYSLSNRV 

       250        260        270        280        290        300 
DTCRNQFRIS VRRVAGGVVS NFVHDNLKVG DIVGVSPPAG NFVYKRSEEN VNRPLLCFAG 

       310        320        330        340        350        360 
GIGITPLIPI IETALLDGRK VNFCYSSRNY VSRPFKQWLE QLKLKYKENL KLKEFFSEES 

       370        380        390        400        410        420 
SVTKEQIVDE VMTRIINEED LEKLDLSECD IYMLGPNNYM RFVKQELVKL GVEPNKVQSE 


FFGPYIP 

Q9URY5 in FASTA format

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