|
|
|
|
|
|
[1]
|
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
TISSUE=Brain;
Li G.Y.,
Cooper N.G.F.;
"Human calcium/calmodulin-dependent protein kinase II: cDNA cloning and gene analysis.";
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
|
[2]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1093/dnares/6.1.63; PubMed=10231032 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T.,
Ishikawa K.,
Suyama M.,
Kikuno R.,
Hirosawa M.,
Miyajima N.,
Tanaka A.,
Kotani H.,
Nomura N.,
Ohara O.;
"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.";
DNA Res. 6:63-70(1999).
|
[3]
|
INTERACTION WITH MPDZ.
DOI=10.1016/j.neuron.2004.08.003; PubMed=15312654 [NCBI, ExPASy, EBI, Israel, Japan]
Krapivinsky G.,
Medina I.,
Krapivinsky L.,
Gapon S.,
Clapham D.E.;
"SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation.";
Neuron 43:563-574(2004).
|
|
|
|
- FUNCTION: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
- ENZYME REGULATION: Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state (By similarity).
- SUBUNIT: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1 (By similarity).
- INTERACTION:
P62158:CALM1; NbExp=1; IntAct=EBI-1383687, EBI-397435;
Q13557:CAMK2D; NbExp=1; IntAct=EBI-1383687, EBI-351018;
Q9NZZ3:CHMP5; NbExp=1; IntAct=EBI-1383687, EBI-751303;
Q92796:DLG3; NbExp=1; IntAct=EBI-1383687, EBI-80440;
- SUBCELLULAR LOCATION: Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic lipid rafts (By similarity).
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
|
| Name | B |
| Isoform ID | Q9UQM7-2 |
| Features which should be applied to build the isoform sequence: VSP_004766. |
|
|
- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
- SIMILARITY: Contains 1 protein kinase domain.
|
|
|
|
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Length: 478 AA [This is the length of the unprocessed precursor] |
Molecular weight: 54030 Da [This is the MW of the unprocessed precursor] |
CRC64: 10800A85CAD724BB [This is a checksum on the sequence] |
|
10 20 30 40 50 60
MATITCTRFT EEYQLFEELG KGAFSVVRRC VKVLAGQEYA AKIINTKKLS ARDHQKLERE
70 80 90 100 110 120
ARICRLLKHP NIVRLHDSIS EEGHHYLIFD LVTGGELFED IVAREYYSEA DASHCIQQIL
130 140 150 160 170 180
EAVLHCHQMG VVHRDLKPEN LLLASKLKGA AVKLADFGLA IEVEGEQQAW FGFAGTPGYL
190 200 210 220 230 240
SPEVLRKDPY GKPVDLWACG VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV
250 260 270 280 290 300
TPEAKDLINK MLTINPSKRI TAAEALKHPW ISHRSTVASC MHRQETVDCL KKFNARRKLK
310 320 330 340 350 360
GAILTTMLAT RNFSGGKSGG NKKSDGVKES SESTNTTIED EDTKVRKQEI IKVTEQLIEA
370 380 390 400 410 420
ISNGGFESYT KMCDPGMTAF EPEALGNLVE GLDFHRFYFE NLWSRNSKPV HTTILNPHIH
430 440 450 460 470
LMGDESACIA YIRITQYLDA GGIPRTAQSE ETRVWHRRDG KWQIVHFHRS GAPSVLPH
|
Q9UQM7 in FASTA format |
|
ExPASy Home page
APAF Australia
