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UniProtKB/Swiss-Prot entry Q9UHG3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PCYOX_HUMAN
Primary accession number Q9UHG3
Secondary accession numbers O94982 Q8N4N5 Q96QM8
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on September 19, 2006 (Sequence version 3)
Annotations were last modified on    September 2, 2008 (Entry version 73)
Name and origin of the protein
Protein name Prenylcysteine oxidase 1 [Precursor]
Synonyms EC 1.8.3.5
Prenylcysteine lyase
Gene name
Name: PCYOX1
Synonyms: KIAA0908, PCL1
ORFNames: UNQ597/PRO1183
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
DOI=10.1074/jbc.274.50.35802; PubMed=10585463 [NCBI, ExPASy, EBI, Israel, Japan]
Tschantz W.R., Zhang L., Casey P.J.;
"Cloning, expression, and cellular localization of a human prenylcysteine lyase.";
J. Biol. Chem. 274:35802-35808(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1093/dnares/5.6.355; PubMed=10048485 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.";
DNA Res. 5:355-364(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Heart, and Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PROTEIN SEQUENCE OF 37-54; 256-266 AND 421-430, AND MASS SPECTROMETRY.
TISSUE=B-cell lymphoma;
Bienvenut W.V.;
Submitted (JUN-2005) to UniProtKB.
[6]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-196; ASN-323 AND ASN-353, AND MASS SPECTROMETRY.
TISSUE=Plasma;
DOI=10.1021/pr0502065; PubMed=16335952 [NCBI, ExPASy, EBI, Israel, Japan]
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.;
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.";
J. Proteome Res. 4:2070-2080(2005).
[7]
UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-162, AND MASS SPECTROMETRY.
DOI=10.1002/pmic.200600410; PubMed=17370265 [NCBI, ExPASy, EBI, Israel, Japan]
Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.;
"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry.";
Proteomics 7:868-874(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF181490; AAF16937.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB020715; BAA74931.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY359063; AAQ89422.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC007029; AAH07029.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC033815; AAH33815.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC051891; AAH51891.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_057381.3; -.
UniGene Hs.591572
3D structure databases
ModBase Q9UHG3.
Organism-specific databases
HGNC HGNC:20588; PCYOX1.
GenAtlas PCYOX1.
MIM 610995; gene. [NCBI / EBI]
PharmGKB PA134959852; -.
GeneCards Q9UHG3.
HUGE KIAA0908.
Gene expression databases
ArrayExpress Q9UHG3; -.
CleanEx HS_PCYOX1; -.
GermOnline ENSG00000116005; Homo sapiens.
Ontologies
GO
GO:0005764; Cellular component: lysosome (non-traceable author statement from UniProtKB).
GO:0016829; Molecular function: lyase activity (non-traceable author statement from UniProtKB).
GO:0030327; Biological process: prenylated protein catabolic process (non-traceable author statement from UniProtKB).
GO:0030329; Biological process: prenylcysteine metabolic process (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR010795; Prenylcys_lyase.
IPR017046; Prenylcysteine_Oxase.
Graphical view of domain structure.
Pfam PF07156; Prenylcys_lyase; 1.
PF07992; Pyr_redox_2; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036292; Prenylcysteine_oxidase; 1.
BLOCKS Q9UHG3.
Proteomic databases
PeptideAtlas Q9UHG3; -.
Genome annotation databases
Ensembl ENSG00000116005; Homo sapiens. [Contig view]
GeneID 51449; -.
KEGG hsa:51449; -.
Phylogenomic databases
HOGENOM Q9UHG3; -.
HOVERGEN Q9UHG3; -.
Other
LinkHub Q9UHG3; -.
SOURCE PCYOX1; Homo sapiens.
ProtoNet Q9UHG3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; FAD; Glycoprotein; Lysosome; Oxidoreductase; Signal; Ubl conjugation.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    27  27     Potential. 
CHAIN   28   505  478     Prenylcysteine oxidase 1. PRO_0000023298
CARBOHYD   196   196        N-linked (GlcNAc...). 
CARBOHYD   323   323        N-linked (GlcNAc...). 
CARBOHYD   353   353        N-linked (GlcNAc...). 
CROSSLNK   162   162        Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin). 
CONFLICT   149   149        S -> F (in Ref. 2; BAA74931). 
CONFLICT   341   341        Q -> H (in Ref. 1; AAF16937). 
Sequence information
Length: 505 AA [This is the length of the unprocessed precursor] Molecular weight: 56640 Da [This is the MW of the unprocessed precursor] CRC64: FB388AF70AF229F5 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGRVVAELVS SLLGLWLLLC SCGCPEGAEL RAPPDKIAII GAGIGGTSAA YYLRQKFGKD 

        70         80         90        100        110        120 
VKIDLFEREE VGGRLATMMV QGQEYEAGGS VIHPLNLHMK RFVKDLGLSA VQASGGLLGI 

       130        140        150        160        170        180 
YNGETLVFEE SNWFIINVIK LVWRYGFQSL RMHMWVEDVL DKFMRIYRYQ SHDYAFSSVE 

       190        200        210        220        230        240 
KLLHALGGDD FLGMLNRTLL ETLQKAGFSE KFLNEMIAPV MRVNYGQSTD INAFVGAVSL 

       250        260        270        280        290        300 
SCSDSGLWAV EGGNKLVCSG LLQASKSNLI SGSVMYIEEK TKTKYTGNPT KMYEVVYQIG 

       310        320        330        340        350        360 
TETRSDFYDI VLVATPLNRK MSNITFLNFD PPIEEFHQYY QHIVTTLVKG ELNTSIFSSR 

       370        380        390        400        410        420 
PIDKFGLNTV LTTDNSDLFI NSIGIVPSVR EKEDPEPSTD GTYVWKIFSQ ETLTKAQILK 

       430        440        450        460        470        480 
LFLSYDYAVK KPWLAYPHYK PPEKCPSIIL HDRLYYLNGI ECAASAMEMS AIAAHNAALL 

       490        500 
AYHRWNGHTD MIDQDGLYEK LKTEL 

Q9UHG3 in FASTA format

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