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UniProtKB/Swiss-Prot entry Q9UBH0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IL1F5_HUMAN
Primary accession number Q9UBH0
Secondary accession numbers Q56AT9 Q7RTZ6
Integrated into Swiss-Prot on November 8, 2002
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 65)
Name and origin of the protein
Protein name Interleukin-1 family member 5
Synonyms IL-1F5
Interleukin-1 delta
IL-1 delta
FIL1 delta
Interleukin-1-like protein 1
IL-1L1
Interleukin-1 HY1
IL-1HY1
Interleukin-1 receptor antagonist homolog 1
IL-1ra homolog 1
IL-1-related protein 3
IL-1RP3
Gene name
Name: IL1F5
Synonyms: FIL1D, IL1HY1, IL1L1, IL1RP3
ORFNames: UNQ1896/PRO4342
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
DOI=10.1074/jbc.275.2.1169; PubMed=10625660 [NCBI, ExPASy, EBI, Israel, Japan]
Smith D.E., Renshaw B.R., Ketchem R.R., Kubin M., Garka K.E., Sims J.E.;
"Four new members expand the IL-1 superfamily.";
J. Biol. Chem. 275:1169-1175(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Fetal skin;
DOI=10.1006/bbrc.1999.1440; PubMed=10512743 [NCBI, ExPASy, EBI, Israel, Japan]
Mulero J.J., Pace A.M., Nelken S.T., Loeb D.B., Correa T.R., Drmanac R., Ford J.E.;
"IL1HY1: a novel interleukin-1 receptor antagonist gene.";
Biochem. Biophys. Res. Commun. 263:702-706(1999).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
DOI=10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S; PubMed=11093146 [NCBI, ExPASy, EBI, Israel, Japan]
Barton J.L., Herbst R., Bosisio D., Higgins L., Nicklin M.J.H.;
"A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities.";
Eur. J. Immunol. 30:3299-3308(2000).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=11466363 [NCBI, ExPASy, EBI, Israel, Japan]
Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S., Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F., Kastelein R.A.;
"Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.";
J. Immunol. 167:1440-1446(2001).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.2000.6184; PubMed=10860666 [NCBI, ExPASy, EBI, Israel, Japan]
Busfield S.J., Comrack C.A., Yu G., Chickering T.W., Smutko J.S., Zhou H., Leiby K.R., Holmgren L.M., Gearing D.P., Pan Y.;
"Identification and gene organization of three novel members of the IL-1 family on human chromosome 2.";
Genomics 66:213-216(2000).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.2002.6751; PubMed=11991722 [NCBI, ExPASy, EBI, Israel, Japan]
Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G., Kornman K.;
"A sequence-based map of the nine genes of the human interleukin-1 cluster.";
Genomics 79:718-725(2002).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT SER-47.
SeattleSNPs program for genomic applications;
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
  • FUNCTION: Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
  • SUBCELLULAR LOCATION: Secreted.
  • TISSUE SPECIFICITY: Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
  • INDUCTION: By phorbol ester (PMA) and lipopolysaccharide (LPS) treatment in macrophage cell line.
  • SIMILARITY: Belongs to the IL-1 family.
  • WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry; URL="http://en.wikipedia.org/wiki/Interleukin_1";.
  • WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il1f5/";.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF201830; AAF25210.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF186094; AAF02757.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ242737; CAB59822.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ242738; CAB59823.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ271338; CAB67704.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF216693; AAF76981.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF230377; AAF91274.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BN000002; CAD29877.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY359117; AAQ89475.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY972853; AAX59031.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC016724; AAY14990.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC024747; AAH24747.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JC7104; JC7104.
RefSeq NP_036407.1; -.
NP_775262.1; -.
UniGene Hs.516301
3D structure databases
HSSP P18510; 1ILR. [HSSP ENTRY / PDB]
SMR Q9UBH0; 2-155.
ModBase Q9UBH0.
Protein-protein interaction databases
IntAct Q9UBH0; -.
Organism-specific databases
H-InvDB HIX0002388; -.
HGNC HGNC:15561; IL1F5.
GenAtlas IL1F5.
MIM 605507; gene. [NCBI / EBI]
PharmGKB PA38388; -.
GeneCards Q9UBH0.
Gene expression databases
ArrayExpress Q9UBH0; -.
CleanEx HS_IL1F5; -.
GermOnline ENSG00000136695; Homo sapiens.
Ontologies
GO
GO:0005152; Molecular function: interleukin-1 receptor antagonist activity (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR003297; IL_rcpt_IL1RA.
IPR000975; Interleukin_1.
IPR003296; InterleukinIL1B.
Graphical view of domain structure.
Pfam PF00340; IL1; 1.
Pfam graphical view of domain structure.
PRINTS PR00264; INTERLEUKIN1.
PR01359; INTRLEUKIN1B.
PR01360; INTRLEUKIN1X.
ProDom PD002536; Interleukin_1; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00125; IL1; 1.
SMART graphical view of domain structure.
PROSITE PS00253; INTERLEUKIN_1; 1.
BLOCKS Q9UBH0.
Genome annotation databases
Ensembl ENSG00000136695; Homo sapiens. [Contig view]
GeneID 26525; -.
KEGG hsa:26525; -.
Phylogenomic databases
HOGENOM Q9UBH0; -.
HOVERGEN Q9UBH0; -.
Other
SOURCE IL1F5; Homo sapiens.
ProtoNet Q9UBH0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytokine; Polymorphism; Secreted.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   155  155     Interleukin-1 family member 5. PRO_0000153642
DISULFID   8   154        By similarity. 
VARIANT   47    47  1     N -> S. VAR_023239 [3D]
Sequence information
Length: 155 AA [This is the length of the unprocessed precursor] Molecular weight: 16962 Da [This is the MW of the unprocessed precursor] CRC64: B96DB5EFA2612E25 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL DASLSPVILG 

        70         80         90        100        110        120 
VQGGSQCLSC GVGQEPTLTL EPVNIMELYL GAKESKSFTF YRRDMGLTSS FESAAYPGWF 

       130        140        150 
LCTVPEADQP VRLTQLPENG GWNAPITDFY FQQCD 

Q9UBH0 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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