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UniProtKB/Swiss-Prot entry Q9UAG7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FHBA_DICDI
Primary accession number Q9UAG7
Secondary accession number Q54D74
Integrated into Swiss-Prot on April 8, 2008
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 50)
Name and origin of the protein
Protein name Flavohemoprotein A
Synonyms EC 1.14.12.17
Flavohemoglobin A
DdFHa
Hemoglobin-like protein A
Nitric oxide dioxygenase A
NO oxygenase A
NOD A
Gene name
Name: fhbA
ORFNames: DDB_0191099
From
Dictyostelium discoideum (Slime mold) [TaxID: 44689] 
Taxonomy Eukaryota; Mycetozoa; Dictyosteliida; Dictyostelium.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND INDUCTION.
STRAIN=AX3-1;
DOI=10.1247/csf.25.47; PubMed=10791894 [NCBI, ExPASy, EBI, Israel, Japan]
Iijima M., Shimizu H., Tanaka Y., Urushihara H.;
"Identification and characterization of two flavohemoglobin genes in Dictyostelium discoideum.";
Cell Struct. Funct. 25:47-55(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature03481; PubMed=15875012 [NCBI, ExPASy, EBI, Israel, Japan]
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB025583; BAA83810.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AAFI02000190; EAL61168.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_629622.1; -.
3D structure databases
HSSP P04252; 2VHB. [HSSP ENTRY / PDB]
ModBase Q9UAG7.
Organism-specific databases
dictyBase DDB0191099; fhbA.
Family and domain databases
InterPro IPR001834; Cyt_B5_reductase.
IPR001709; FPN_cyt_redctse.
IPR012292; Globin.
IPR000971; Globin_subset.
IPR008333; OxRdtase_FAD-bd.
IPR001433; OxRdtase_FAD/NAD_bd.
Graphical view of domain structure.
Gene3D G3DSA:1.10.490.10; Globin_related; 1.
Pfam PF00970; FAD_binding_6; 1.
PF00042; Globin; 1.
PF00175; NAD_binding_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00406; CYTB5RDTASE.
PR00371; FPNCR.
PROSITE PS51384; FAD_FR; 1.
PS01033; GLOBIN; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9UAG7.
Genome annotation databases
GeneID 3386245; -.
KEGG ddi:DDB_0191099; -.
Other
ProtoNet Q9UAG7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Detoxification; FAD; Flavoprotein; Heme; Iron; Metal-binding; NAD; NADP; Oxidoreductase; Oxygen transport; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   397  397     Flavohemoprotein A. PRO_0000327849
DOMAIN   151   266  116     FAD-binding FR-type. 
NP_BIND   208   211  4     FAD (By similarity). 
NP_BIND   279   284  6     NADP (By similarity). 
NP_BIND   390   393  4     FAD (By similarity). 
REGION   1   141  141     Globin (By similarity). 
REGION   150   397  248     Reductase (By similarity). 
REGION   272   397  126     NAD or NADP-binding (By similarity). 
ACT_SITE   94    94        Charge relay system (By similarity). 
ACT_SITE   136   136        Charge relay system (By similarity). 
METAL   84    84        Iron (heme proximal ligand) (By similarity). 
BINDING   189   189        FAD (By similarity). 
SITE   30    30  1     Involved in heme-bound ligand stabilization and O-O bond activation (By similarity). 
SITE   83    83  1     Influences the redox potential of the prosthetic heme and FAD groups (By similarity). 
SITE   389   389  1     Influences the redox potential of the prosthetic heme and FAD groups (By similarity). 
Sequence information
Length: 397 AA [This is the length of the unprocessed precursor] Molecular weight: 43925 Da [This is the MW of the unprocessed precursor] CRC64: 9641037821908183 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSLSQQSISI IKATVPVLQV HGVNITTTFY RNMFKANPQL LNIFNHSNQR EGKQQNALAN 

        70         80         90        100        110        120 
TVLQAAIHID KLNELNLAPI VHKHVALGVL PEHYPIVGTN LLGAIKEVLQ DAATDEILGA 

       130        140        150        160        170        180 
WGEAYGVIAQ AFIDAEAALY KVTEEQIGGW RDTREFIVDR KVEESSNIIS FYFKPADGKP 

       190        200        210        220        230        240 
IATYIPGQYI TIKVPLTLEN GEQRTHIRHY SLSDTPSEQY YRISVKKEDA LKKSDPNGVV 

       250        260        270        280        290        300 
SNHLHANVKV GDKVLLSPPA GDYVVDQLSS NPILLVSGGV GITPLLSMAK ATLAKQPERE 

       310        320        330        340        350        360 
VTFVHSSKNK QYQPFANELS QLEKSNKVKV STVHSETDGQ ITKDKLEKFI NPSQIKDTKV 

       370        380        390 
FICGPVSFMS AINKQLIELG YPKENISYEI FGPLTNV 

Q9UAG7 in FASTA format

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