[1]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=Philippines; Fan J., Brindley P.J.; "Cloning and expression in Escherichia coli of a cysteine dioxygenase from Schistosoma japonicum."; Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: L-cysteine + O₂ = 3-sulfinoalanine.
COFACTOR: Binds 1 iron ion per subunit (By similarity).
PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2 .
PTM: The thioether cross-link between Cys-102 and Tyr-178 plays a structural role through stabilizing the ferrous ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen (By similarity).
SIMILARITY: Belongs to the cysteine dioxygenase family.

Copyright

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Cross-references

Sequence databases

EMBL

AF091540; AAD52701.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q9U8F1.

Family and domain databases

InterPro

IPR010300; Cys_dOase_I.
Graphical view of domain structure.

Pfam

PF05995; CDO_I; 1.
Pfam graphical view of domain structure.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Dioxygenase; Iron; Metal-binding; Oxidoreductase; Thioether bond.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 212`	`212`	`Cysteine dioxygenase.`	`PRO_0000206613`
`METAL`	`95 95`		`Iron; catalytic (By similarity).`
`METAL`	`97 97`		`Iron; catalytic (By similarity).`
`METAL`	`161 161`		`Iron; catalytic (By similarity).`
`CROSSLNK`	`102 178`		`3'-(S-cysteinyl)-tyrosine (Cys-Tyr) (By similarity).`

Sequence information

Length: 212 AA [This is the length of the unprocessed precursor]

Molecular weight: 25035 Da [This is the MW of the unprocessed precursor]

CRC64: 39BE01713721F46C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSMYTHQSNN ELIPLKTVST LNDLIKTIRI IFNQKEINVN EIHKILNDFQ CDFTEWQKYI 

        70         80         90        100        110        120 
YFNKTHYTRN LIDEGNGRYN LFLLCWSEDQ GTRIHDHSGA HCFVKLIKGC IKETIFEWPK 

       130        140        150        160        170        180 
YFTVEKSNYS INQIDLPLTV KSVSEMRPGD VTYMHDKIGI HRLHNPSTTE TAITLHLYFP 

       190        200        210 
PYTNSMIFEE STSRMKKMDV TFHSKFGKQI PQ

Q9U8F1 in FASTA format

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View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools