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UniProtKB/Swiss-Prot entry Q9QZU7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name BODG_RAT
Primary accession number Q9QZU7
Secondary accession numbers None
Integrated into Swiss-Prot on June 20, 2002
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 44)
Name and origin of the protein
Protein name Gamma-butyrobetaine dioxygenase
Synonyms EC 1.14.11.1
Gamma-butyrobetaine,2-oxoglutarate dioxygenase
Gamma-butyrobetaine hydroxylase
Gamma-BBH
Gene name
Name: Bbox1
Synonyms: Bbh
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
STRAIN=Sprague-Dawley;
TISSUE=Liver;
DOI=10.1016/S1388-1981(99)00135-3; PubMed=10526231 [NCBI, ExPASy, EBI, Israel, Japan]
Galland S., Le Borgne F., Bouchard F., Georges B., Clouet P., Grand-Jean F., Demarquoy J.;
"Molecular cloning and characterization of the cDNA encoding the rat liver gamma-butyrobetaine hydroxylase.";
Biochim. Biophys. Acta 1441:85-92(1999).
[2]
 PARTIAL PROTEIN SEQUENCE.
TISSUE=Liver;
DOI=10.1006/bbrc.1998.9343; PubMed=9753662 [NCBI, ExPASy, EBI, Israel, Japan]
Vaz F.M., van Gool S., Ofman R., Ijlst L., Wanders R.J.A.;
"Carnitine biosynthesis: identification of the cDNA encoding human gamma-butyrobetaine hydroxylase.";
Biochem. Biophys. Res. Commun. 250:506-510(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF160958; AAD53264.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_072151.1; -.
UniGene Rn.16333
3D structure databases
ModBase Q9QZU7.
Organism-specific databases
RGD 619756; Bbox1.
Gene expression databases
ArrayExpress Q9QZU7; -.
GermOnline ENSRNOG00000004536; Rattus norvegicus.
Ontologies
GO
GO:0008336; Molecular function: gamma-butyrobetaine dioxygenase activity (inferred from mutant phenotype from UniProtKB).
GO:0045329; Biological process: carnitine biosynthetic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR012775; 2-oxoglut_dOase.
IPR003819; Taurine_dOase.
Graphical view of domain structure.
Pfam PF02668; TauD; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR02409; carnitine_bodg; 1.
BLOCKS Q9QZU7.
Genome annotation databases
Ensembl ENSRNOG00000004536; Rattus norvegicus. [Contig view]
GeneID 64564; -.
KEGG rno:64564; -.
Phylogenomic databases
HOVERGEN Q9QZU7; -.
Other
ProtoNet Q9QZU7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Carnitine biosynthesis; Cytoplasm; Dioxygenase; Direct protein sequencing; Iron; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   387  387     Gamma-butyrobetaine dioxygenase. PRO_0000207087
Sequence information
Length: 387 AA [This is the length of the unprocessed precursor] Molecular weight: 44546 Da [This is the MW of the unprocessed precursor] CRC64: 357804BFB35BF274 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MHCAILKAEA VDGARLMQIF WHDGAESLYP AVWLRDNCQC SDCYLHSAKA RKLLLEALDV 

        70         80         90        100        110        120 
NIRMDDLTFD QKKVYITWPN GHYSEFEANW LKKRCFSQEA RAGLQGELFL PECQYWGSEL 

       130        140        150        160        170        180 
QLPTLNFEDV LNDDDHAYKW LSSLKKVGIV RLTGAADKRG EIIKLGKRIG FLYLTFYGHT 

       190        200        210        220        230        240 
WQVQDKIDAN NVAYTTGKLS FHTDYPALHH PPGVQLLHCI KQTVTGGDSE IVDGFNVCQK 

       250        260        270        280        290        300 
LKEKNPQAFS ILSSTFVDFT DIGVDYCDFS VQSKHKIIEL DDKGQVVRIN FNNATRDTVF 

       310        320        330        340        350        360 
DVPIERVQPF YAALKEFVDL MNSKEYKYTF KMNPGDVITF DNWRLLHGRR SYEAGTEISR 

       370        380 
HLEGAYADWD VVMSRLRILR QRVMNGN
Q9QZU7 in FASTA format

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