[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Muscle; PubMed=9364765 [NCBI, ExPASy, EBI, Israel, Japan] Mannen H., Tsoi S.C.-M., Krushkal J.S., Li W.-H., Li S.S.-L.; "The cDNA cloning and molecular evolution of reptile and pigeon lactate dehydrogenase isozymes."; Mol. Biol. Evol. 14:1081-1087(1997).

Comments

CATALYTIC ACTIVITY: (S)-lactate + NAD⁺ = pyruvate + NADH.
PATHWAY: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1 .
SUBUNIT: Homotetramer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the LDH/MDH superfamily. LDH family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L76362; AAD46976.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P00339; 9LDT. [HSSP ENTRY / PDB]

SMR

Q9PW07; 2-332.

ModBase

Q9PW07.

Family and domain databases

InterPro

IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000102; Lac_mal_DH; 1.

TIGRFAMs

TIGR01771; L-LDH-NAD; 1.

PROSITE

PS00064; L_LDH; 1.

BLOCKS

Q9PW07.

Phylogenomic databases

HOVERGEN

Q9PW07; -.

Other

ProtoNet

Q9PW07.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Glycolysis; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 332`	`331`	`L-lactate dehydrogenase A chain.`	`PRO_0000168421`
`NP_BIND`	`29 57`	`29`	`NAD (By similarity).`
`ACT_SITE`	`193 193`		`Proton acceptor (By similarity).`
`BINDING`	`99 99`		`NAD (By similarity).`
`BINDING`	`106 106`		`Substrate (By similarity).`
`BINDING`	`138 138`		`NAD or substrate (By similarity).`
`BINDING`	`169 169`		`Substrate (By similarity).`
`BINDING`	`248 248`		`Substrate (By similarity).`

Sequence information

Length: 332 AA [This is the length of the unprocessed precursor]

Molecular weight: 36527 Da [This is the MW of the unprocessed precursor]

CRC64: 51AC33BBDD494660 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSLKDQLIHN VHKEEHSHAH NKISVVGVGA VGMACAISIL MKDLADELAL VDVVEDKLKG 

        70         80         90        100        110        120 
EMLDLQHGSL FLRTPKIVSG KDYSVTAHSK LVIVTAGARQ QEGESRLNLV QRNVNIFKVI 

       130        140        150        160        170        180 
IPNVVKYSPD CKLLIVSNPV DILTYVAWKI SGFPKHRVIG SGCNLDSARF RHLMGERLGI 

       190        200        210        220        230        240 
HPLSCHGWIV GEHGDSSVPV WSGVNVAGVS LKALHPDMGT DADKEHWKEV HKQVVDSAYE 

       250        260        270        280        290        300 
VIKLKGYTSW AIGLSVADLA ETIMKNLRRV HPISTVVKGM HGIKEDVFLS VPCVLGSSGI 

       310        320        330 
TDVVKMILKP EEEDKLRKSA DTLWGIQKEL QF

Q9PW07 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools