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UniProtKB/Swiss-Prot entry Q9PW06

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDHA_ALLMI
Primary accession number Q9PW06
Secondary accession numbers None
Integrated into Swiss-Prot on November 16, 2001
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 48)
Name and origin of the protein
Protein name L-lactate dehydrogenase A chain
Synonyms LDH-A
EC 1.1.1.27
Gene name
Name: LDHA
From
Alligator mississippiensis (American alligator) [TaxID: 8496] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Crocodylidae; Alligatorinae; Alligator.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Muscle;
PubMed=9364765 [NCBI, ExPASy, EBI, Israel, Japan]
Mannen H., Tsoi S.C.-M., Krushkal J.S., Li W.-H., Li S.S.-L.;
"The cDNA cloning and molecular evolution of reptile and pigeon lactate dehydrogenase isozymes.";
Mol. Biol. Evol. 14:1081-1087(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L79951; AAD46977.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P00339; 9LDT. [HSSP ENTRY / PDB]
ModBase Q9PW06.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
ProtoNet Q9PW06.
Phylogenomic databases
HOVERGEN Q9PW06; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   332  331     L-lactate dehydrogenase A chain. PRO_0000168422
NP_BIND   29    57  29     NAD (By similarity). 
ACT_SITE   193   193        Proton acceptor (By similarity). 
BINDING   99    99        NAD (By similarity). 
BINDING   106   106        Substrate (By similarity). 
BINDING   138   138        NAD or substrate (By similarity). 
BINDING   169   169        Substrate (By similarity). 
BINDING   248   248        Substrate (By similarity). 
Sequence information
Length: 332 AA [This is the length of the unprocessed precursor] Molecular weight: 36784 Da [This is the MW of the unprocessed precursor] CRC64: FD6295D8EFFC2A48 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSVKEHLIHN VHKEEHGHAH NKITVVGVGA VGMACAISIL MKDLADELAL VDVVEDKLRG 

        70         80         90        100        110        120 
EMLDLQHGSL FLRTPKIVSG KDYSVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI 

       130        140        150        160        170        180 
IPNVVKHSPD CKLLVVSNPV DIWTYVAWKI SGFPKHRVIG SGCNLDSARF RYLMGERLGI 

       190        200        210        220        230        240 
HSLSCHGWIV GEHGDSSVPV WSGVNVAGVS LKALHPELGT DADKEHWKEV HKQVVDSAYE 

       250        260        270        280        290        300 
VIKLKGYTSW AIGLSVADLA ETVMKNLRRV HPISTMVKGM YGIKDDVFLS VPCVLGYHGI 

       310        320        330 
TDVVMMTLKS EEEEKLRKSA DTLWGIQKEL QF
Q9PW06 in FASTA format

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