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UniProtKB/Swiss-Prot entry Q9PLW0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LEU3_CAMJE
Primary accession number Q9PLW0
Secondary accession number Q0P7R3
Integrated into Swiss-Prot on October 19, 2002
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 45)
Name and origin of the protein
Protein name 3-isopropylmalate dehydrogenase
Synonyms EC 1.1.1.85
Beta-IPM dehydrogenase
IMDH
3-IPM-DH
Gene name
Name: leuB
OrderedLocusNames: Cj1718c
From
Campylobacter jejuni [TaxID: 197] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Campylobacteraceae; Campylobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=NCTC 11168 / Serotype O:2;
DOI=10.1038/35001088; PubMed=10688204 [NCBI, ExPASy, EBI, Israel, Japan]
Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S., Barrell B.G.;
"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences.";
Nature 403:665-668(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL111168; CAL35812.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B81270; B81270.
3D structure databases
HSSP P37412; 1CNZ. [HSSP ENTRY / PDB]
ModBase Q9PLW0.
Enzyme and pathway databases
BioCyc CJEJ192222:CJ1718C-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003862; Molecular function: 3-isopropylmalate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009098; Biological process: leucine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01033; -; 1.
PBIL [Tree]
InterPro IPR004429; 3-isopropylmalate_DHase.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF13; IPMDH; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00169; leuB; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q9PLW0.
Genome annotation databases
GenomeReviews AL111168_GR; Cj1718c.
KEGG cje:Cj1718c; -.
CMR Q9PLW0; Cj1718c.
Other
ProtoNet Q9PLW0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Leucine biosynthesis; Magnesium; Manganese; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   358  358     3-isopropylmalate dehydrogenase. PRO_0000083675
NP_BIND   77    90  14     NAD (By similarity). 
NP_BIND   279   291  13     NAD (By similarity). 
METAL   221   221        Magnesium or manganese (By similarity). 
METAL   245   245        Magnesium or manganese (By similarity). 
METAL   249   249        Magnesium or manganese (By similarity). 
BINDING   98    98        Substrate (By similarity). 
BINDING   108   108        Substrate (By similarity). 
BINDING   137   137        Substrate (By similarity). 
BINDING   221   221        Substrate (By similarity). 
SITE   144   144  1     Important for catalysis (By similarity). 
SITE   189   189  1     Important for catalysis (By similarity). 
Sequence information
Length: 358 AA [This is the length of the unprocessed precursor] Molecular weight: 39368 Da [This is the MW of the unprocessed precursor] CRC64: 26B811645E7FFA83 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKTYKVAVLA GDGIGPLVMK EALKILTFIA QKYNFSFEFN EAKIGGASID AYGVALSDET 

        70         80         90        100        110        120 
LKLCEQSDAI LFGSVGGPKW DNLPIDQRPE RASLLPLRKH FNLFANLRPC KIYESLTHAS 

       130        140        150        160        170        180 
PLKNEIIQKG VDILCVRELT GGIYFGKQDL GKESAYDTEI YTKKEIERIA RIAFESARIR 

       190        200        210        220        230        240 
KKKVHLIDKA NVLASSILWR EVVANVAKDY QDINLEYMYV DNAAMQIVKN PSIFDVMLCS 

       250        260        270        280        290        300 
NLFGDILSDE LAAINGSLGL LSSASLNDKG FGLYEPAGGS APDIAHLNIA NPIAQILSAA 

       310        320        330        340        350 
LMLKYSFKEE QAAQDIENAI SLALAQGKMT KDLNAKSYLN TDEMGDCILE ILKENDNG
Q9PLW0 in FASTA format

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