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UniProtKB/Swiss-Prot entry Q9P8I0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PUT2_EMENI
Primary accession number Q9P8I0
Secondary accession number Q5BCJ7
Integrated into Swiss-Prot on May 16, 2003
Sequence was last modified on May 1, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 42)
Name and origin of the protein
Protein name Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial [Precursor]
Synonyms P5C dehydrogenase
EC 1.5.1.12
Gene name
Name: prnC
ORFNames: AN1733
From
Emericella nidulans (Aspergillus nidulans) [TaxID: 162425] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae; Emericella.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Demais S., Gavrias V., Scazzocchio C.;
"Primary structure of the nuclear prnC gene involved in the mitochondrial pathway for proline utilization in Aspergillus nidulans.";
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=FGSC 4;
DOI=10.1038/nature04341; PubMed=16372000 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.";
Nature 438:1105-1115(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF252630; AAF72527.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AACD01000027; EAA64019.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_659337.1; -.
3D structure databases
ModBase Q9P8I0.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR005931; d-1-pyrroline-5-COlate_DHase-1.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01236; D1pyr5carbox1; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS Q9P8I0.
Genome annotation databases
GeneID 2875278; -.
KEGG ani:AN1733.2; -.
Other
ProtoNet Q9P8I0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Mitochondrion; NAD; Oxidoreductase; Proline metabolism; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     ?        Mitochondrion (Potential). 
CHAIN   ?   572        Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial. PRO_0000007176
NP_BIND   300   305  6     NAD (By similarity). 
ACT_SITE   320   320        Proton acceptor (By similarity). 
ACT_SITE   354   354        Nucleophile (By similarity). 
SITE   215   215  1     Transition state stabilizer (By similarity). 
CONFLICT   149   149        L -> V (in Ref. 1; AAF72527). 
Sequence information
Length: 572 AA [This is the length of the unprocessed precursor] Molecular weight: 61936 Da [This is the MW of the unprocessed precursor] CRC64: 249FBB3461A9C3DD [This is a checksum on the sequence]
        10         20         30         40         50         60 
MQSSMLLRVR ALPKTASVLS RTKTATYATY KVPRIDNEPN KHYAAGSPDR KALQEALART 

        70         80         90        100        110        120 
QRNAPLSVPL VIAGKEVKSS SSLTQSNPAS HGPVATYSNA TAKDVQAAIE SALEARKSWA 

       130        140        150        160        170        180 
STPFADRASV FLKAADLIST KYRYDVMALT MHGQGKNAWQ AEIDSAAELC DFFRFGVKYA 

       190        200        210        220        230        240 
EDLYAQQPVH HAPGVWNRVE YRPLEGFVYA ISPFNFTAIG GNLAGAPALM GNVVVWKPSP 

       250        260        270        280        290        300 
SAIASNWLVH QILLEAGLPK NVIQFVPGEA EEVTKTVLDH PDFAALHFTG STNVFRNLYG 

       310        320        330        340        350        360 
QISTRVAAGK YRSYPRIVGE TGGKNFHLIH KSADIRNAAV QTVRGAFEYQ GQKCSATSRV 

       370        380        390        400        410        420 
YVASSIADSF LEQVASEAKS LKVGPPSDFT NFCGPVIHEA SFTKLAKVID EAKNDPELEL 

       430        440        450        460        470        480 
LAGGSYDSSK GWYIQPTVYR TTNPDHPLLT RELFGPILVV YAYPDATEAD FARIAQKIDA 

       490        500        510        520        530        540 
TGEYGLTGSV FAQDREALAV ANDVLRNAAG NFYINCKSTG AVVGQQPFGG ARASGTNDKA 

       550        560        570 
GSGNLLSRFV SLRSIKEEFV PTYKVAYPSN EA 

Q9P8I0 in FASTA format

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