[1]
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NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
DOI=10.1016/S1357-2725(02)00024-9; PubMed=12009299 [NCBI, ExPASy, EBI, Israel, Japan]
Deng Y.,
Wang Z.,
Ying K.,
Gu S.,
Ji C.,
Huang Y.,
Gu X.,
Wang Y.,
Xu Y.,
Li Y.,
Xie Y.,
Mao Y.;
"NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties.";
Int. J. Biochem. Cell Biol. 34:1035-1050(2002).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
DOI=10.1007/s00432-002-0413-7; PubMed=12669231 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang J.,
Zhang W.,
Zou D.,
Chen G.,
Wan T.,
Zhang M.,
Cao X.;
"Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL-60 leukemia cells.";
J. Cancer Res. Clin. Oncol. 129:76-83(2003).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
Okaze H.,
Hayashi A.,
Kozuma S.,
Saito T.;
"A novel protein related to guanosine monophosphate reductase.";
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
Li W.B.,
Gruber C.,
Jessee J.,
Polayes D.;
"Full-length cDNA libraries and normalization.";
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L.,
Schick M.,
Neubert P.,
Schatten R.,
Henze S.,
Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung, and Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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- FUNCTION: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation.
- CATALYTIC ACTIVITY: Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH.
- TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes.
- SIMILARITY: Belongs to the IMPDH/GMPR family.
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