ID   SOX_HUMAN               Reviewed;         390 AA.
AC   Q9P0Z9; Q96H28; Q9C070;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 2.
DT   25-NOV-2008, entry version 61.
DE   RecName: Full=Peroxisomal sarcosine oxidase;
DE            Short=PSO;
DE            EC=1.5.3.1;
DE            EC=1.5.3.7;
DE   AltName: Full=L-pipecolate oxidase;
DE   AltName: Full=L-pipecolic acid oxidase;
GN   Name=PIPOX; Synonyms=LPIPOX, PSO;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10772957; DOI=10.1006/bbrc.2000.2575;
RA   Ijlst L., de Kromme I., Oostheim W., Wanders R.J.A.;
RT   "Molecular cloning and expression of human L-pipecolate oxidase.";
RL   Biochem. Biophys. Res. Commun. 270:1101-1105(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=20115082; PubMed=10642506; DOI=10.1042/0264-6021:3450487;
RA   Dodt G., Kim D.G., Reimann S.A., Reuber B.E., McCabe K., Gould S.J.,
RA   Mihalik S.J.;
RT   "L-pipecolic acid oxidase, a human enzyme essential for the
RT   degradation of L-pipecolic acid, is most similar to the monomeric
RT   sarcosine oxidases.";
RL   Biochem. J. 345:487-494(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Adrenal gland;
RX   MEDLINE=20402571; PubMed=10931946; DOI=10.1073/pnas.160270997;
RA   Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA   Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H.,
RA   Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J.,
RA   Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M.,
RA   Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.;
RT   "Gene expression profiling in the human hypothalamus-pituitary-adrenal
RT   axis and full-length cDNA cloning.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Metabolizes sarcosine, L-pipecolic acid and L-proline.
CC   -!- CATALYTIC ACTIVITY: Sarcosine + H(2)O + O(2) = glycine +
CC       formaldehyde + H(2)O(2).
CC   -!- CATALYTIC ACTIVITY: L-pipecolate + O(2) = 2,3,4,5-
CC       tetrahydropyridine-2-carboxylate + H(2)O(2).
CC   -!- COFACTOR: Binds 1 FAD per subunit.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Peroxisome.
CC   -!- SIMILARITY: Belongs to the MSOX/MTOX family.
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DR   EMBL; AF134593; AAF37331.1; -; mRNA.
DR   EMBL; AF136970; AAG49431.1; -; mRNA.
DR   EMBL; BC008960; AAH08960.1; -; mRNA.
DR   PIR; JC7256; JC7256.
DR   RefSeq; NP_057602.2; -.
DR   UniGene; Hs.462585; -.
DR   HSSP; P40859; 1EL5.
DR   IntAct; Q9P0Z9; -.
DR   Ensembl; ENSG00000179761; Homo sapiens.
DR   GeneID; 51268; -.
DR   KEGG; hsa:51268; -.
DR   H-InvDB; HIX0019115; -.
DR   HGNC; HGNC:17804; PIPOX.
DR   HPA; HPA015567; -.
DR   PharmGKB; PA33332; -.
DR   HOGENOM; Q9P0Z9; -.
DR   HOVERGEN; Q9P0Z9; -.
DR   DrugBank; DB00145; Glycine.
DR   NextBio; 54463; -.
DR   ArrayExpress; Q9P0Z9; -.
DR   CleanEx; HS_PIPOX; -.
DR   GermOnline; ENSG00000179761; Homo sapiens.
DR   GO; GO:0005777; C:peroxisome; TAS:ProtInc.
DR   GO; GO:0050031; F:L-pipecolate oxidase activity; IEA:EC.
DR   GO; GO:0008115; F:sarcosine oxidase activity; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0046653; P:tetrahydrofolate metabolic process; IEA:InterPro.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR006281; SoxA_mon.
DR   Pfam; PF01266; DAO; 1.
DR   TIGRFAMs; TIGR01377; soxA_mon; 1.
PE   2: Evidence at transcript level;
KW   FAD; Flavoprotein; Oxidoreductase; Peroxisome.
FT   CHAIN         1    390       Peroxisomal sarcosine oxidase.
FT                                /FTId=PRO_0000213773.
FT   NP_BIND       9     39       FAD (Potential).
FT   MOTIF       388    390       Microbody targeting signal (Potential).
FT   MOD_RES     319    319       S-8alpha-FAD cysteine (By similarity).
FT   CONFLICT    376    390       PFRISRFPSLGKAHL -> AFSNQPFPKPGQSPPLTSGQKP
FT                                PFCAQEPVSQMEKMSQMKGVSLRYHPFLLPRLNPP (in
FT                                Ref. 3).
FT   CONFLICT    386    386       G -> A (in Ref. 2; AAF37331).
SQ   SEQUENCE   390 AA;  44066 MW;  581ADDA6F5D19C0F CRC64;
     MAAQKDLWDA IVIGAGIQGC FTAYHLAKHR KRILLLEQFF LPHSRGSSHG QSRIIRKAYL
     EDFYTRMMHE CYQIWAQLEH EAGTQLHRQT GLLLLGMKEN QELKTIQANL SRQRVEHQCL
     SSEELKQRFP NIRLPRGEVG LLDNSGGVIY AYKALRALQD AIRQLGGIVR DGEKVVEINP
     GLLVTVKTTS RSYQAKSLVI TAGPWTNQLL RPLGIEMPLQ TLRINVCYWR EMVPGSYGVS
     QAFPCFLWLG LCPHHIYGLP TGEYPGLMKV SYHHGNHADP EERDCPTART DIGDVQILSS
     FVRDHLPDLK PEPAVIESCM YTNTPDEQFI LDRHPKYDNI VIGAGFSGHG FKLAPVVGKI
     LYELSMKLTP SYDLAPFRIS RFPSLGKAHL
//