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UniProtKB/Swiss-Prot entry Q9P0Z9


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SOX_HUMAN
Primary accession number Q9P0Z9
Secondary accession numbers Q96H28 Q9C070
Integrated into Swiss-Prot on January 23, 2002
Sequence was last modified on October 11, 2004 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 59)
Name and origin of the protein
Protein name Peroxisomal sarcosine oxidase
Synonyms PSO
EC 1.5.3.1
EC 1.5.3.7
L-pipecolate oxidase
L-pipecolic acid oxidase
Gene name
Name: PIPOX
Synonyms: LPIPOX, PSO
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1006/bbrc.2000.2575; PubMed=10772957 [NCBI, ExPASy, EBI, Israel, Japan]
Ijlst L., de Kromme I., Oostheim W., Wanders R.J.A.;
"Molecular cloning and expression of human L-pipecolate oxidase.";
Biochem. Biophys. Res. Commun. 270:1101-1105(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1042/0264-6021:3450487; PubMed=10642506 [NCBI, ExPASy, EBI, Israel, Japan]
Dodt G., Kim D.G., Reimann S.A., Reuber B.E., McCabe K., Gould S.J., Mihalik S.J.;
"L-pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases.";
Biochem. J. 345:487-494(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Adrenal gland;
DOI=10.1073/pnas.160270997; PubMed=10931946 [NCBI, ExPASy, EBI, Israel, Japan]
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.;
"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.";
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Muscle;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF134593; AAF37331.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF136970; AAG49431.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC008960; AAH08960.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JC7256; JC7256.
RefSeq NP_057602.2; -.
UniGene Hs.462585
3D structure databases
HSSP P40859; 1EL5. [HSSP ENTRY / PDB]
ModBase Q9P0Z9.
Organism-specific databases
H-InvDB HIX0019115; -.
HGNC HGNC:17804; PIPOX.
GenAtlas PIPOX.
HPA HPA015567; -.
PharmGKB PA33332; -.
GeneCards Q9P0Z9.
Gene expression databases
ArrayExpress Q9P0Z9; -.
CleanEx HS_PIPOX; -.
GermOnline ENSG00000179761; Homo sapiens.
Ontologies
GO
GO:0005777; Cellular component: peroxisome (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR006076; FAD-dep_OxRdtase.
IPR006281; SoxA_mon.
Graphical view of domain structure.
Pfam PF01266; DAO; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01377; soxA_mon; 1.
BLOCKS Q9P0Z9.
Genome annotation databases
Ensembl ENSG00000179761; Homo sapiens. [Contig view]
GeneID 51268; -.
KEGG hsa:51268; -.
Phylogenomic databases
HOGENOM Q9P0Z9; -.
HOVERGEN Q9P0Z9; -.
Other
DrugBank DB00145; Glycine.
ProtoNet Q9P0Z9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
FAD; Flavoprotein; Oxidoreductase; Peroxisome.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   390  390     Peroxisomal sarcosine oxidase. PRO_0000213773
NP_BIND   9    39  31     FAD (Potential). 
MOTIF   388   390  3     Microbody targeting signal (Potential). 
MOD_RES   319   319        S-8alpha-FAD cysteine (By similarity). 
CONFLICT   376   390        PFRISRFPSLGKAHL -> AFSNQPFPKPGQSPPLTSGQKPPFCAQEPVSQMEKMSQMK GVSLRYHPFLLPRLNPP (in Ref. 3). 
CONFLICT   386   386        G -> A (in Ref. 2; AAF37331). 
Sequence information
Length: 390 AA [This is the length of the unprocessed precursor] Molecular weight: 44066 Da [This is the MW of the unprocessed precursor] CRC64: 581ADDA6F5D19C0F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAAQKDLWDA IVIGAGIQGC FTAYHLAKHR KRILLLEQFF LPHSRGSSHG QSRIIRKAYL 

        70         80         90        100        110        120 
EDFYTRMMHE CYQIWAQLEH EAGTQLHRQT GLLLLGMKEN QELKTIQANL SRQRVEHQCL 

       130        140        150        160        170        180 
SSEELKQRFP NIRLPRGEVG LLDNSGGVIY AYKALRALQD AIRQLGGIVR DGEKVVEINP 

       190        200        210        220        230        240 
GLLVTVKTTS RSYQAKSLVI TAGPWTNQLL RPLGIEMPLQ TLRINVCYWR EMVPGSYGVS 

       250        260        270        280        290        300 
QAFPCFLWLG LCPHHIYGLP TGEYPGLMKV SYHHGNHADP EERDCPTART DIGDVQILSS 

       310        320        330        340        350        360 
FVRDHLPDLK PEPAVIESCM YTNTPDEQFI LDRHPKYDNI VIGAGFSGHG FKLAPVVGKI 

       370        380        390 
LYELSMKLTP SYDLAPFRIS RFPSLGKAHL 

Q9P0Z9 in FASTA format

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