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UniProtKB/Swiss-Prot entry Q9NZH8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IL1F9_HUMAN
Primary accession number Q9NZH8
Secondary accession numbers Q56B91 Q6UVX7 Q7RTZ9
Integrated into Swiss-Prot on November 8, 2002
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 68)
Name and origin of the protein
Protein name Interleukin-1 family member 9
Synonyms IL-1F9
Interleukin-1 homolog 1
IL-1H1
Interleukin-1 epsilon
IL-1 epsilon
IL-1-related protein 2
IL-1RP2
Gene name
Name: IL1F9
Synonyms: IL1E, IL1H1, IL1RP2
ORFNames: UNQ2456/PRO5737
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Keratinocyte;
DOI=10.1074/jbc.275.14.10308; PubMed=10744718 [NCBI, ExPASy, EBI, Israel, Japan]
Kumar S., McDonnell P.C., Lehr R., Tierney L., Tzimas M.N., Griswold D.E., Capper E.A., Tal-Singer R., Wells G.I., Doyle M.L., Young P.R.;
"Identification and initial characterization of four novel members of the interleukin-1 family.";
J. Biol. Chem. 275:10308-10314(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND CHARACTERIZATION.
TISSUE=Epithelium;
PubMed=11466363 [NCBI, ExPASy, EBI, Israel, Japan]
Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S., Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F., Kastelein R.A.;
"Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.";
J. Immunol. 167:1440-1446(2001).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.2000.6184; PubMed=10860666 [NCBI, ExPASy, EBI, Israel, Japan]
Busfield S.J., Comrack C.A., Yu G., Chickering T.W., Smutko J.S., Zhou H., Leiby K.R., Holmgren L.M., Gearing D.P., Pan Y.;
"Identification and gene organization of three novel members of the IL-1 family on human chromosome 2.";
Genomics 66:213-216(2000).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.2002.6751; PubMed=11991722 [NCBI, ExPASy, EBI, Israel, Japan]
Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G., Kornman K.;
"A sequence-based map of the nine genes of the human interleukin-1 cluster.";
Genomics 79:718-725(2002).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
SeattleSNPs variation discovery resource;
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
  • FUNCTION: Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
  • SUBCELLULAR LOCATION: Secreted.
  • ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.
    Name1
    Isoform IDQ9NZH8-1
    This is the isoform sequence displayed in this entry.
    Name2
    Isoform IDQ9NZH8-2
    Note: No experimental confirmation available.
    Features which should be applied to build the isoform sequence: VSP_013002.
  • TISSUE SPECIFICITY: Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up-regulated in lesional psoriasis skin.
  • INDUCTION: By TNF-alpha and by IFN-gamma in keratinocytes.
  • SIMILARITY: Belongs to the IL-1 family.
  • WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry; URL="http://en.wikipedia.org/wiki/Interleukin_1";.
  • WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il1f9/";.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF200492; AAF69248.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF206696; AAG35670.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BN000002; CAD29874.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY359111; AAQ89469.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY968311; AAX59035.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC016724; AAY14987.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC096721; AAH96721.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC098130; AAH98130.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC098155; AAH98155.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC098337; AAH98337.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00021343; -.
IPI00432063; -.
RefSeq NP_062564.1; -.
UniGene Hs.211238
3D structure databases
HSSP P18510; 1ILR. [HSSP ENTRY / PDB]
ModBase Q9NZH8.
PTM databases
PhosphoSite Q9NZH8; -.
Organism-specific databases
GeneCards GC02P113451; -.
H-InvDB HIX0029828; -.
HGNC HGNC:15741; IL1F9.
GenAtlas IL1F9.
MIM 605542; gene. [NCBI / EBI]
PharmGKB PA38395; -.
Gene expression databases
ArrayExpress Q9NZH8; -.
Bgee Q9NZH8; -.
CleanEx HS_IL1F9; -.
GermOnline ENSG00000136688; Homo sapiens.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (inferred from electronic annotation from UniProtKB-KW).
GO:0005125; Molecular function: cytokine activity (inferred from electronic annotation from UniProtKB-KW).
GO:0005152; Molecular function: interleukin-1 receptor antagonist activity (inferred from electronic annotation from InterPro).
GO:0007267; Biological process: cell-cell signaling (traceable author statement from ProtInc).
GO:0006955; Biological process: immune response (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR003297; IL_rcpt_IL1RA.
IPR000975; Interleukin_1.
Graphical view of domain structure.
Pfam PF00340; IL1; 1.
Pfam graphical view of domain structure.
PRINTS PR00264; INTERLEUKIN1.
PR01360; INTRLEUKIN1X.
ProDom PD002536; Interleukin_1; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00125; IL1; 1.
SMART graphical view of domain structure.
PROSITE PS00253; INTERLEUKIN_1; FALSE_NEG.
Proteomic databases
PRIDE Q9NZH8; -.
Genome annotation databases
Ensembl ENSG00000136688; Homo sapiens. [Contig view]
GeneID 56300; -.
KEGG hsa:56300; -.
Phylogenomic databases
HOGENOM Q9NZH8; -.
HOVERGEN Q9NZH8; -.
OMA Q9NZH8; PCKYPES.
Other
NextBio 61963; -.
SOURCE IL1F9; Homo sapiens.
ProtoNet Q9NZH8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cytokine; Polymorphism; Secreted.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   169  169     Interleukin-1 family member 9. PRO_0000153648
VAR_SEQ   19    54        MCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPV -> I (in isoform 2). VSP_013002
VARIANT   69    69  1     Q -> K (in dbSNP:rs6707930 [NCBI]). VAR_024505 
Sequence information
Length: 169 AA [This is the length of the unprocessed precursor] Molecular weight: 18721 Da [This is the MW of the unprocessed precursor] CRC64: F00A9243706F4154 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MRGTPGDADG GGRAVYQSMC KPITGTINDL NQQVWTLQGQ NLVAVPRSDS VTPVTVAVIT 

        70         80         90        100        110        120 
CKYPEALEQG RGDPIYLGIQ NPEMCLYCEK VGEQPTLQLK EQKIMDLYGQ PEPVKPFLFY 

       130        140        150        160 
RAKTGRTSTL ESVAFPDWFI ASSKRDQPII LTSELGKSYN TAFELNIND 

Q9NZH8 in FASTA format

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