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UniProtKB/Swiss-Prot entry Q9NZH7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IL1F8_HUMAN
Primary accession number Q9NZH7
Secondary accession numbers Q53SR6 Q7RTZ7 Q9UHA5
Integrated into Swiss-Prot on November 8, 2002
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 60)
Name and origin of the protein
Protein name Interleukin-1 family member 8
Synonyms IL-1F8
Interleukin-1 eta
IL-1 eta
FIL1 eta
Interleukin-1 homolog 2
IL-1H2
Gene name
Name: IL1F8
Synonyms: IL1H2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Osteoclastoma;
DOI=10.1074/jbc.275.14.10308; PubMed=10744718 [NCBI, ExPASy, EBI, Israel, Japan]
Kumar S., McDonnell P.C., Lehr R., Tierney L., Tzimas M.N., Griswold D.E., Capper E.A., Tal-Singer R., Wells G.I., Doyle M.L., Young P.R.;
"Identification and initial characterization of four novel members of the interleukin-1 family.";
J. Biol. Chem. 275:10308-10314(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
DOI=10.1074/jbc.275.2.1169; PubMed=10625660 [NCBI, ExPASy, EBI, Israel, Japan]
Smith D.E., Renshaw B.R., Ketchem R.R., Kubin M., Garka K.E., Sims J.E.;
"Four new members expand the IL-1 superfamily.";
J. Biol. Chem. 275:1169-1175(2000).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.2002.6751; PubMed=11991722 [NCBI, ExPASy, EBI, Israel, Japan]
Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G., Kornman K.;
"A sequence-based map of the nine genes of the human interleukin-1 cluster.";
Genomics 79:718-725(2002).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT CYS-36.
SeattleSNPs variation discovery resource;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF200494; AAF69250.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF201833; AAF25213.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BN000002; CAD29876.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
DQ224343; ABA60896.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC016724; AAY14989.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00005404; -.
IPI00218473; -.
RefSeq NP_055253.2; -.
NP_775270.1; -.
UniGene Hs.278909
3D structure databases
ModBase Q9NZH7.
Organism-specific databases
GeneCards GC02M113496; -.
H-InvDB HIX0029829; -.
HGNC HGNC:15564; IL1F8.
GenAtlas IL1F8.
MIM 605508; gene. [NCBI / EBI]
PharmGKB PA38391; -.
Gene expression databases
ArrayExpress Q9NZH7; -.
Bgee Q9NZH7; -.
CleanEx HS_IL1F8; -.
GermOnline ENSG00000136696; Homo sapiens.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (inferred from electronic annotation from UniProtKB-KW).
GO:0005125; Molecular function: cytokine activity (inferred from electronic annotation from UniProtKB-KW).
GO:0005149; Molecular function: interleukin-1 receptor binding (non-traceable author statement from UniProtKB).
GO:0006955; Biological process: immune response (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR000975; Interleukin_1.
Graphical view of domain structure.
ProDom PD002536; Interleukin_1; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00125; IL1; 1.
SMART graphical view of domain structure.
PROSITE PS00253; INTERLEUKIN_1; FALSE_NEG.
Proteomic databases
PRIDE Q9NZH7; -.
Genome annotation databases
Ensembl ENSG00000136696; Homo sapiens. [Contig view]
GeneID 27177; -.
KEGG hsa:27177; -.
Phylogenomic databases
HOGENOM Q9NZH7; -.
HOVERGEN Q9NZH7; -.
OMA Q9NZH7; GIHTCIN.
Other
NextBio 49986; -.
SOURCE IL1F8; Homo sapiens.
ProtoNet Q9NZH7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cytokine; Polymorphism; Secreted.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   164  164     Interleukin-1 family member 8. PRO_0000153646
VAR_SEQ   88   164        LQGSQDNIGKDTCWKLVGIHTCINLDVRESCFMGTLDQWG IGVGRKKWKSSFQHHHLRKKDKDFSSMRTNIGMPGRM -> EKNIMDLYVEKKAQKPFLFFHNKEGSTSVFQSVSYPGWFI ATSTTSGQPIFLTKERGITNNTNFYLDSVE (in isoform 2). VSP_002657
VARIANT   36    36  1     R -> C. VAR_025057 
Sequence information
Length: 164 AA [This is the length of the unprocessed precursor] Molecular weight: 18522 Da [This is the MW of the unprocessed precursor] CRC64: F0D2099F4A357A0A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGN 

        70         80         90        100        110        120 
MVYLGIKGKD LCLFCAEIQG KPTLQLKLQG SQDNIGKDTC WKLVGIHTCI NLDVRESCFM 

       130        140        150        160 
GTLDQWGIGV GRKKWKSSFQ HHHLRKKDKD FSSMRTNIGM PGRM 

Q9NZH7 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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