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UniProtKB/Swiss-Prot entry Q9NR61


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DLL4_HUMAN
Primary accession number Q9NR61
Secondary accession numbers Q3KP23 Q9NQT9
Integrated into Swiss-Prot on April 27, 2001
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 72)
Name and origin of the protein
Protein name Delta-like protein 4 [Precursor]
Synonym Drosophila Delta homolog 4
Gene name
Name: DLL4
ORFNames: UNQ1895/PRO4341
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=10837024 [NCBI, ExPASy, EBI, Israel, Japan]
Shutter J.R., Scully S., Fan W., Richards W.G., Kitajewski J., Deblandre G.A., Kintner C.R., Stark K.L.;
"Dll4, a novel Notch ligand expressed in arterial endothelium.";
Genes Dev. 14:1313-1318(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Sakano S.;
"Human Delta-2, Notch ligand gene.";
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=11134954 [NCBI, ExPASy, EBI, Israel, Japan]
Yoneya T., Tahara T., Nagao K., Yamada Y., Yamamoto T., Miyatani S., Nishikawa M.;
"Molecular cloning of Delta-4, a new mouse and human Notch ligand.";
J. Biochem. 129:27-34(2001).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PROTEIN SEQUENCE OF 27-41.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 33-685.
TISSUE=Placenta;
Mailhos C., Modlich U., Lewis J., Harris A., Bicknell R., Ish-Horowicz D.;
"A novel Delta gene expressed in embryonic and tumour vasculature.";
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF253468; AAF76427.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB036931; BAB16085.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB043894; BAB18581.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358894; AAQ89253.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC106950; AAI06951.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF279305; AAF81912.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JC7570; JC7570.
RefSeq NP_061947.1; -.
UniGene Hs.511076
3D structure databases
HSSP P00740; 1EDM. [HSSP ENTRY / PDB]
ModBase Q9NR61.
Enzyme and pathway databases
Reactome REACT_299; Signaling by Notch.
Organism-specific databases
H-InvDB HIX0038067; -.
HGNC HGNC:2910; DLL4.
GenAtlas DLL4.
MIM 605185; gene. [NCBI / EBI]
PharmGKB PA27366; -.
GeneCards Q9NR61.
Gene expression databases
ArrayExpress Q9NR61; -.
CleanEx HS_DLL4; -.
GermOnline ENSG00000128917; Homo sapiens.
Ontologies
GO
GO:0005112; Molecular function: Notch binding (traceable author statement from ProtInc).
GO:0008015; Biological process: blood circulation (traceable author statement from ProtInc).
GO:0007165; Biological process: signal transduction (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR001774; DSL.
IPR006210; EGF.
IPR000152; EGF-type_Asp/Asn_hydroxyl_CS.
IPR001438; EGF_2.
IPR000742; EGF_3.
IPR001881; EGF_Ca_bd.
IPR013111; EGF_extracell.
IPR006209; EGF_like.
IPR013032; EGF_like_reg_CS.
IPR011651; Notch_ligand_N.
Graphical view of domain structure.
Pfam PF01414; DSL; 1.
PF00008; EGF; 6.
PF07974; EGF_2; 1.
PF07657; MNNL; 1.
Pfam graphical view of domain structure.
PRINTS PR00010; EGFBLOOD.
SMART SM00051; DSL; 1.
SM00181; EGF; 6.
SM00179; EGF_CA; 2.
SMART graphical view of domain structure.
PROSITE PS00010; ASX_HYDROXYL; 1.
PS51051; DSL; 1.
PS00022; EGF_1; 8.
PS01186; EGF_2; 7.
PS50026; EGF_3; 8.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9NR61.
Genome annotation databases
Ensembl ENSG00000128917; Homo sapiens. [Contig view]
GeneID 54567; -.
KEGG hsa:54567; -.
Phylogenomic databases
HOGENOM Q9NR61; -.
HOVERGEN Q9NR61; -.
Other
SOURCE DLL4; Homo sapiens.
ProtoNet Q9NR61.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Developmental protein; Differentiation; Direct protein sequencing; EGF-like domain; Glycoprotein; Membrane; Notch signaling pathway; Repeat; Signal; Transmembrane; Ubl conjugation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    26  26      
CHAIN   27   685  659     Delta-like protein 4. PRO_0000007512
TOPO_DOM   27   529  503     Extracellular (Potential). 
TRANSMEM   530   550  21     Potential. 
TOPO_DOM   551   685  135     Cytoplasmic (Potential). 
DOMAIN   173   217  45     DSL. 
DOMAIN   218   251  34     EGF-like 1. 
DOMAIN   252   282  31     EGF-like 2. 
DOMAIN   284   322  39     EGF-like 3. 
DOMAIN   324   360  37     EGF-like 4. 
DOMAIN   362   400  39     EGF-like 5. 
DOMAIN   402   438  37     EGF-like 6. 
DOMAIN   440   476  37     EGF-like 7. 
DOMAIN   480   518  39     EGF-like 8. 
CARBOHYD   108   108        N-linked (GlcNAc...) (Potential). 
CARBOHYD   183   183        N-linked (GlcNAc...) (Potential). 
CARBOHYD   205   205        N-linked (GlcNAc...) (Potential). 
CARBOHYD   393   393        N-linked (GlcNAc...) (Potential). 
DISULFID   222   233        By similarity. 
DISULFID   226   239        By similarity. 
DISULFID   241   250        By similarity. 
DISULFID   253   264        By similarity. 
DISULFID   259   270        By similarity. 
DISULFID   272   281        By similarity. 
DISULFID   288   300        By similarity. 
DISULFID   294   310        By similarity. 
DISULFID   312   321        By similarity. 
DISULFID   328   339        By similarity. 
DISULFID   333   348        By similarity. 
DISULFID   350   359        By similarity. 
DISULFID   366   377        By similarity. 
DISULFID   371   388        By similarity. 
DISULFID   390   399        By similarity. 
DISULFID   406   417        By similarity. 
DISULFID   411   426        By similarity. 
DISULFID   428   437        By similarity. 
DISULFID   444   455        By similarity. 
DISULFID   449   464        By similarity. 
DISULFID   466   475        By similarity. 
DISULFID   484   495        By similarity. 
DISULFID   489   506        By similarity. 
DISULFID   508   517        By similarity. 
Sequence information
Length: 685 AA [This is the length of the unprocessed precursor] Molecular weight: 74605 Da [This is the MW of the unprocessed precursor] CRC64: 6CF89D3C220ACC89 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAAASRSASG WALLLLVALW QQRAAGSGVF QLQLQEFINE RGVLASGRPC EPGCRTFFRV 

        70         80         90        100        110        120 
CLKHFQAVVS PGPCTFGTVS TPVLGTNSFA VRDDSSGGGR NPLQLPFNFT WPGTFSLIIE 

       130        140        150        160        170        180 
AWHAPGDDLR PEALPPDALI SKIAIQGSLA VGQNWLLDEQ TSTLTRLRYS YRVICSDNYY 

       190        200        210        220        230        240 
GDNCSRLCKK RNDHFGHYVC QPDGNLSCLP GWTGEYCQQP ICLSGCHEQN GYCSKPAECL 

       250        260        270        280        290        300 
CRPGWQGRLC NECIPHNGCR HGTCSTPWQC TCDEGWGGLF CDQDLNYCTH HSPCKNGATC 

       310        320        330        340        350        360 
SNSGQRSYTC TCRPGYTGVD CELELSECDS NPCRNGGSCK DQEDGYHCLC PPGYYGLHCE 

       370        380        390        400        410        420 
HSTLSCADSP CFNGGSCRER NQGANYACEC PPNFTGSNCE KKVDRCTSNP CANGGQCLNR 

       430        440        450        460        470        480 
GPSRMCRCRP GFTGTYCELH VSDCARNPCA HGGTCHDLEN GLMCTCPAGF SGRRCEVRTS 

       490        500        510        520        530        540 
IDACASSPCF NRATCYTDLS TDTFVCNCPY GFVGSRCEFP VGLPPSFPWV AVSLGVGLAV 

       550        560        570        580        590        600 
LLVLLGMVAV AVRQLRLRRP DDGSREAMNN LSDFQKDNLI PAAQLKNTNQ KKELEVDCGL 

       610        620        630        640        650        660 
DKSNCGKQQN HTLDYNLAPG PLGRGTMPGK FPHSDKSLGE KAPLRLHSEK PECRISAICS 

       670        680 
PRDSMYQSVC LISEERNECV IATEV 

Q9NR61 in FASTA format

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