NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=NIES-296;
DOI=10.1038/35001059; PubMed=10688199 [NCBI, ExPASy, EBI, Israel, Japan]
Lemieux C., Otis C., Turmel M.;
"Ancestral chloroplast genome in Mesostigma viride reveals an early branch of green plant evolution.";
Nature 403:649-652(2000).

Comments

FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
CATALYTIC ACTIVITY: Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO₂.
COFACTOR: Thiamine pyrophosphate.
SUBUNIT: Heterodimer of an alpha and a beta chain (By similarity).
SUBCELLULAR LOCATION: Plastid, chloroplast.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF166114; AAF43837.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_038396.1; -.

3D structure databases

HSSP

Q8ZUR7; 1IK6. [HSSP ENTRY / PDB]

ModBase

Q9MUR4.

Family and domain databases

InterPro

IPR005476; Transketo_C.
IPR005475; Transketo_Cen_R.
IPR015941; Transketolase_C-like.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.920; Transketo_C_like; 1.

Pfam

PF02779; Transket_pyr; 1.
PF02780; Transketolase_C; 1.
Pfam graphical view of domain structure.

BLOCKS

Q9MUR4.

Genome annotation databases

GeneID

800962; -.

Other

ProtoNet

Q9MUR4.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Chloroplast; Glycolysis; Oxidoreductase; Plastid; Pyruvate; Thiamine pyrophosphate.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 327`	`327`	`Pyruvate dehydrogenase E1 component subunit beta.`	`PRO_0000162218`
`BINDING`	`60 60`		`Thiamine pyrophosphate (By similarity).`

Sequence information

Length: 327 AA [This is the length of the unprocessed precursor]

Molecular weight: 36005 Da [This is the MW of the unprocessed precursor]

CRC64: 8E8D7CD1ADD64E5A [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTVRFLFEAL NMAIDEEMAR NDKVALLGED IGHYGGSYKV TQNLYAKYGE HRVIDTPIAE 

        70         80         90        100        110        120 
NSFVGAAIGA AMTGLVTVVE GMNMGFILLA FSQISNNMGM LSATSGGHYH IPIVLRGPGG 

       130        140        150        160        170        180 
VGKQLGAEHS QRLECYFQSV PGLQIVACST PYNAKGLLKS AIRSKNPIFF LEHVLLYNLK 

       190        200        210        220        230        240 
AEVPDNDYVL PLEKAEIVRQ GNDITILTYS RMRYNVIQAV KVLVEKGYDP EIIDLISLKP 

       250        260        270        280        290        300 
FDIETIGKSI QKTHKVLIVE ESMMTGGISN VLQSLILENF FDDLDNRPMC LSSPNVPTPY 

       310        320 
SGPLEEVSIV QTADIIESVE QILTNKM

Q9MUR4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools