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UniProtKB/Swiss-Prot entry Q9LVG4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name APRR3_ARATH
Primary accession number Q9LVG4
Secondary accession numbers None
Integrated into Swiss-Prot on September 27, 2004
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 49)
Name and origin of the protein
Protein name Two-component response regulator-like APRR3
Synonym Pseudo-response regulator 3
Gene name
Name: APRR3
OrderedLocusNames: At5g60100
ORFNames: MGO3.8
From
Arabidopsis thaliana (Mouse-ear cress) [TaxID: 3702] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE, AND FUNCTION.
DOI=10.1093/pcp/pcd043; PubMed=11100772 [NCBI, ExPASy, EBI, Israel, Japan]
Matsushika A., Makino S., Kojima M., Mizuno T.;
"Circadian waves of expression of the APRR1/TOC1 family of pseudo-response regulators in Arabidopsis thaliana: insight into the plant circadian clock.";
Plant Cell Physiol. 41:1002-1012(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1093/dnares/7.1.31; PubMed=10718197 [NCBI, ExPASy, EBI, Israel, Japan]
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.;
"Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones.";
DNA Res. 7:31-63(2000).
[3]
GENE FAMILY.
PubMed=10945350 [NCBI, ExPASy, EBI, Israel, Japan]
Makino S., Kiba T., Imamura A., Hanaki N., Nakamura A., Suzuki T., Taniguchi M., Ueguchi C., Sugiyama T., Mizuno T.;
"Genes encoding pseudo-response regulators: insight into His-to-Asp phosphorelay and circadian rhythm in Arabidopsis thaliana.";
Plant Cell Physiol. 41:791-803(2000).
[4]
INDUCTION, AND PHOSPHORYLATION BY WNK1.
DOI=10.1093/pcp/pcf084; PubMed=12091722 [NCBI, ExPASy, EBI, Israel, Japan]
Murakami-Kojima M., Nakamichi N., Yamashino T., Mizuno T.;
"The APRR3 component of the clock-associated APRR1/TOC1 quintet is phosphorylated by a novel protein kinase belonging to the WNK family, the gene for which is also transcribed rhythmically in Arabidopsis thaliana.";
Plant Cell Physiol. 43:675-683(2002).
Comments
  • FUNCTION: Controls photoperiodic flowering response. Seems to be one of the component of the circadian clock. Expression of several members of the ARR-like family is controlled by circadian rhythm. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock.
  • INTERACTION:
    Q9LKL2:APRR1; NbExp=1; IntAct=EBI-1606968, EBI-618423;
  • SUBCELLULAR LOCATION: Nucleus (Probable).
  • INDUCTION: Expressed with a circadian rhythm showing a peak in the evening.
  • PTM: Phosphorylated by WNK1.
  • SIMILARITY: Belongs to the ARR-like family.
  • SIMILARITY: Contains 1 CCT domain.
  • SIMILARITY: Contains 1 response regulatory domain.
  • CAUTION: Lacks the phospho-accepting Asp (here Glu-116), present in the receiver domain, which is one of the conserved features of two-component response regulators (ARRs) family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB046956; BAB13744.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB019231; BAA96939.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_568919.1; -.
UniGene At.1676
3D structure databases
ModBase Q9LVG4.
Protein-protein interaction databases
IntAct Q9LVG4; -.
Organism-specific databases
GeneFarm 4342; 437.
TAIR At5g60100; -.
Gene expression databases
ArrayExpress Q9LVG4; -.
GermOnline AT5G60100; Arabidopsis thaliana.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR010402; CCT.
IPR001789; Sig_transdc_resp-reg_receiver.
Graphical view of domain structure.
Pfam PF06203; CCT; 1.
PF00072; Response_reg; 1.
Pfam graphical view of domain structure.
ProDom PD000039; Response_reg; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00448; REC; 1.
SMART graphical view of domain structure.
PROSITE PS51017; CCT; 1.
PS50110; RESPONSE_REGULATORY; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9LVG4.
ProtoNet Q9LVG4.
Genome annotation databases
GeneID 836132; -.
GenomeReviews BA000015_GR; AT5G60100.
KEGG ath:AT5G60100; -.
NMPDR fig|3702.1.peg.28015; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Transcription; Transcription regulation; Two-component regulatory system.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   495  495     Two-component response regulator-like APRR3. PRO_0000081436
DOMAIN   65   183  119     Response regulatory. 
DOMAIN   442   484  43     CCT. 
COILED   349   372  24     Potential. 
Sequence information
Length: 495 AA [This is the length of the unprocessed precursor] Molecular weight: 55286 Da [This is the MW of the unprocessed precursor] CRC64: 933B89129FA1974F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MCFNNIETGD EVETERQVFG SSEEDEFRVE DTARNTNNVQ ISQQQQQPLA HVVKWERYLP 

        70         80         90        100        110        120 
VRSLKVLLVE NDDSTRHIVT ALLKNCSYEV TAVPDVLEAW RILEDEKSCI DLVLTEVDMP 

       130        140        150        160        170        180 
VHSGTGLLSK IMSHKTLKNI PVIMMSSHDS MVLVFKCLSN GAVDFLVKPI RKNELKNLWQ 

       190        200        210        220        230        240 
HVWRRCHSSS GSGSESGIHD KKSVKPESTQ GSENDASISD EHRNESGSSG GLSNQDGGSD 

       250        260        270        280        290        300 
NGSGTQSSWT KRASDTKSTS PSNQFPDAPN KKGTYENGCA HVNRLKEAED QKEQIGTGSQ 

       310        320        330        340        350        360 
TGMSMSKKAE EPGDLEKNAK YSVQALERNN DDTLNRSSGN SQVESKAPSS NREDLQSLEQ 

       370        380        390        400        410        420 
TLKKTREDRD YKVGDRSVLR HSNLSAFSKY NNGATSAKKA PEENVESCSP HDSPIAKLLG 

       430        440        450        460        470        480 
SSSSSDNPLK QQSSGSDRWA QREAALMKFR LKRKERCFEK KVRYHSRKKL AEQRPHVKGQ 

       490 
FIRKRDDHKS GSEDN 

Q9LVG4 in FASTA format

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