NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=10708384 [NCBI, ExPASy, EBI, Israel, Japan]
Canovas D., Vargas C., Kneip S., Moron M.J., Ventosa A., Bremer E., Nieto J.J.;
"Genes for the synthesis of the osmoprotectant glycine betaine from choline in the moderately halophilic bacterium Halomonas elongata DSM 3043.";
Microbiology 146:455-463(2000).

Comments

CATALYTIC ACTIVITY: Betaine aldehyde + NAD⁺ + H₂O = betaine + NADH.
PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1 .
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ238780; CAB77175.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P56533; 1A4S. [HSSP ENTRY / PDB]

ModBase

Q9L4K1.

Ontologies

GO:0008802;	Molecular function: betaine-aldehyde dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019285;	Biological process: glycine betaine biosynthetic process from choline (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00804; -; 1.
PBIL [Tree]

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR011264; Betaine_Ald_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01804; BADH; 1.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 489`	`489`	`Betaine aldehyde dehydrogenase.`	`PRO_0000056545`
`NP_BIND`	`228 233`	`6`	`NAD (By similarity).`
`ACT_SITE`	`251 251`		`By similarity.`
`ACT_SITE`	`285 285`		`By similarity.`

Sequence information

Length: 489 AA [This is the length of the unprocessed precursor]

Molecular weight: 52333 Da [This is the MW of the unprocessed precursor]

CRC64: 42AFE892DA57DD4B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTAQSAQPLY IGGRPVDATS GETFTVTNPY DGSLLATIGQ ASQADVDSAV QAAQRGQREW 

        70         80         90        100        110        120 
AAMTGMERSR ILLRAVALLR ERNDELAELE TRNTGKPISE TASVDIVTGA DALEYYAGLA 

       130        140        150        160        170        180 
PAIEGSQIPL RDTRLVYTRR EPLGVIGAIG AWNYPIQIAC WKAAPALAAG NAIVFKPSEV 

       190        200        210        220        230        240 
TPLTALKLAE IFTEAGLPDG VFNVVQGDGR VGAMLTEHEG IAKVSFTGEV GTGKKVMAAA 

       250        260        270        280        290        300 
GGSTLKDVTM ELGGKSPLIV FADADLDRAA DAAMMANFYS SGQICTNGTR VFVERSAKEA 

       310        320        330        340        350        360 
FEAKLVERVA RIKAGDPMDP SVNFGPLVSF EHQEKVLSYI ALGKEQGARV LAGGDAWNSG 

       370        380        390        400        410        420 
EWAKGAWAAP TVFTDCTDEM RVVKEEIFGP VMSVLAFDDE EEVIRRANNT KYGLAAGVFS 

       430        440        450        460        470        480 
ESLNRAHRVI HQLEAGICWI NTWGESPSEM PVGGYKESGI GRENGVETLN HYTQTKSVQI 


EMGPFESVF

Q9L4K1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools