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UniProtKB/Swiss-Prot entry Q9JRT1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information

Entry name

CYSH_NEIMB

Primary accession number

Q9JRT1

Secondary accession numbers

None

Integrated into Swiss-Prot on

August 22, 2003

Sequence was last modified on

October 1, 2000 (Sequence version 1)

Annotations were last modified on

July 22, 2008 (Entry version 37)

Name and origin of the protein

Protein name

Phosphoadenosine phosphosulfate reductase

Synonyms

EC 1.8.4.8
PAPS reductase, thioredoxin dependent
PAdoPS reductase
3'-phosphoadenylylsulfate reductase
PAPS sulfotransferase

Gene names

	Name:	cysH1
	OrderedLocusNames:	NMB1155
and
	Name:	cysH2
	OrderedLocusNames:	NMB1193

From

Neisseria meningitidis serogroup B

[TaxID: 491]

[HAMAP proteome]

Taxonomy

Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae; Neisseria.

Protein existence

3: Inferred from homology;

References

[1]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MC58 / Serogroup B;
DOI=10.1126/science.287.5459.1809; PubMed=10710307 [NCBI, ExPASy, EBI, Israel, Japan]
Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C.;
"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58.";
Science 287:1809-1815(2000).

Comments

FUNCTION: Reduction of activated sulfate into sulfite.
CATALYTIC ACTIVITY: Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.
PATHWAY: Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the PAPS reductase family. CysH subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE002098; AAF41541.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AE002098; AAF41576.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

C81111; C81111.

RefSeq

NP_274183.1; -.
NP_274219.1; -.

3D structure databases

ModBase

Q9JRT1.

Enzyme and pathway databases

BioCyc

NMEN122586:NMB_1155-MON; -.
NMEN122586:NMB_1193-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004604;	Molecular function: phosphoadenylyl-sulfate reductase (thioredoxin) activity (inferred from electronic annotation from HAMAP).
GO:0019379;	Biological process: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00063; -; 1.
PBIL [Tree]

InterPro

IPR011798; APS_reductase.
IPR002500; PAPS_reduct.
IPR014729; Rossmann-like_a/b/a_fold.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.

Pfam

PF01507; PAPS_reduct; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR02055; APS_reductase; 1.

BLOCKS

Q9JRT1.

Genome annotation databases

GeneID

903576; -.
903613; -.

GenomeReviews

AE002098_GR; NMB1155.
AE002098_GR; NMB1193.

KEGG

nme:NMB1155; -.
nme:NMB1193; -.

TIGR

NMB1155; -.
NMB1193; -.

Phylogenomic databases

HOGENOM

Q9JRT1; -.

Other

ProtoNet

Q9JRT1.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 246`	`246`		`Phosphoadenosine phosphosulfate reductase.`	`PRO_0000100636`

Sequence information

Length: 246 AA [This is the length of the unprocessed precursor]

Molecular weight: 28091 Da [This is the MW of the unprocessed precursor]

CRC64: FAD0206EF23FEB98 [This is a checksum on the sequence]

        10         20         30         40         50         60 
METTLFKPAL WQIPHIGSGG ETALAEKTET LKQRLHRIVG SHRDARFASS LAAEDMVITD 

        70         80         90        100        110        120 
LIAGENLNIG IFTLDTGLLH TETLNLLDRL GRAYPHLRIK RFRPVREDAD RYVESKGRFA 

       130        140        150        160        170        180 
FYDSVEARRE CCRIRKTEPL NRAIAGADAW LTGQRREQSA TRTELPFAEY DAGRGIGKYN 

       190        200        210        220        230        240 
PIFDWSEHDV WAYILANNVP YNDLYRQGFP SIGCDPCTRP VKAGEDIRAG RWWWEGRNSK 


ECGLHK

Q9JRT1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools