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UniProtKB/Swiss-Prot entry Q9JLJ2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AL9A1_MOUSE
Primary accession number Q9JLJ2
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 2005
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 56)
Name and origin of the protein
Protein name 4-trimethylaminobutyraldehyde dehydrogenase
Synonyms TMABADH
EC 1.2.1.47
Aldehyde dehydrogenase family 9 member A1
EC 1.2.1.3
Gene name
Name: Aldh9a1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
DOI=10.1074/jbc.275.10.7390; PubMed=10702312 [NCBI, ExPASy, EBI, Israel, Japan]
Vaz F.M., Fouchier S.W., Ofman R., Sommer M., Wanders R.J.A.;
"Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis.";
J. Biol. Chem. 275:7390-7394(2000).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF170919; AAF43599.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC003297; AAH03297.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
UniGene Mm.330055
3D structure databases
HSSP P56533; 1A4S. [HSSP ENTRY / PDB]
ModBase Q9JLJ2.
PTM databases
PhosphoSite Q9JLJ2; -.
2D gel databases
REPRODUCTION-2DPAGE Q9JLJ2; -.
Organism-specific databases
MGI MGI:1861622; Aldh9a1.
Gene expression databases
ArrayExpress Q9JLJ2; -.
CleanEx MM_ALDH9A1; -.
GermOnline ENSMUSG00000026687; Mus musculus.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from direct assay from MGI).
GO:0009437; Biological process: carnitine metabolic process (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS Q9JLJ2.
Genome annotation databases
Ensembl ENSMUSG00000026687; Mus musculus. [Contig view]
NMPDR fig|10090.3.peg.1427; -.
Phylogenomic databases
HOVERGEN Q9JLJ2; -.
Other
SOURCE Aldh9a1; Mus musculus.
ProtoNet Q9JLJ2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Cytoplasm; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   494  493     4-trimethylaminobutyraldehyde dehydrogenase. PRO_0000056486
NP_BIND   232   237  6     NAD (By similarity). 
ACT_SITE   254   254        Potential. 
ACT_SITE   288   288        Potential. 
MOD_RES   2     2        N-acetylserine (By similarity). 
Sequence information
Length: 494 AA [This is the length of the unprocessed precursor] Molecular weight: 53515 Da [This is the MW of the unprocessed precursor] CRC64: CBB27755330E0A23 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSTGTFVVSQ PLNYRGGARV EPVDASGTEK AFEPATGRVI ATFACSGEKE VNLAVENAKA 

        70         80         90        100        110        120 
AFKLWSKKSG LERCQVLLEA ARIIKERKDE IATVETINNG KSIFEARLDV DTCWQCLEYY 

       130        140        150        160        170        180 
AGLAASMAGE HIQLPGGSFG YTRREPLGVC VGIGAWNYPF QIACWKSAPA LACGNAMIFK 

       190        200        210        220        230        240 
PSPFTPVSAL LLAEIYTKAG APPGLFNVVQ GGAATGQFLC HHREVAKISF TGSVPTGVKI 

       250        260        270        280        290        300 
MEMSAKGVKP ITLELGGKSP LIIFSDCNME NAVKGALMAN FLTQGQVCCN GTRVFVQKEI 

       310        320        330        340        350        360 
ADKFINEVVK QTQKIKLGDP LLEDTRMGPL INAPHLERVL GFVKLAKEQG ATVLCGGEVY 

       370        380        390        400        410        420 
VPEDPKLKHG YYMTPCILTN CRDDMTCVKE EIFGPVMSIL TFGTEAEVLE RANDTTFGLA 

       430        440        450        460        470        480 
AGVFTRDIQR AHRVAAELQA GTCYINNYNV SPVELPFGGY KKSGFGRENG RVTIEYYSQL 

       490 
KTVCVEMGDV ESAF
Q9JLJ2 in FASTA format

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