ID   DHB8_CALJA              Reviewed;         134 AA.
AC   Q9GME3;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   04-NOV-2008, entry version 43.
DE   RecName: Full=Estradiol 17-beta-dehydrogenase 8;
DE            EC=1.1.1.62;
DE   AltName: Full=Testosterone 17-beta-dehydrogenase 8;
DE            EC=1.1.1.63;
DE   AltName: Full=17-beta-hydroxysteroid dehydrogenase 8;
DE            Short=17-beta-HSD 8;
DE   Flags: Fragment;
GN   Name=HSD17B8;
OS   Callithrix jacchus (Common marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix.
OX   NCBI_TaxID=9483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=21098712; PubMed=11165027; DOI=10.1016/S0303-7207(00)00421-4;
RA   Husen B., Adamski J., Rune G.M., Einspanier A.;
RT   "Mechanisms of estradiol inactivation in primate endometrium.";
RL   Mol. Cell. Endocrinol. 171:179-185(2001).
CC   -!- FUNCTION: Uses estradiol as its preferred substrate.
CC   -!- CATALYTIC ACTIVITY: Estradiol-17-beta + NAD(P)(+) = estrone +
CC       NAD(P)H.
CC   -!- CATALYTIC ACTIVITY: Testosterone + NAD(+) = androst-4-ene-3,17-
CC       dione + NADH.
CC   -!- PATHWAY: Steroid biosynthesis; estrogen biosynthesis.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family.
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DR   EMBL; AF272012; AAG01114.1; -; mRNA.
DR   HSSP; Q93X62; 1EDO.
DR   HOVERGEN; Q9GME3; -.
DR   GO; GO:0004303; F:estradiol 17-beta-dehydrogenase activity; IEA:EC.
DR   GO; GO:0050327; F:testosterone 17-beta-dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002198; DHase_sc/Rdtase_SDR.
DR   InterPro; IPR002347; Glc/ribitol_DHase.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR19410; ADH_short_C2; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   Lipid synthesis; NAD; Oxidoreductase; Steroid biosynthesis.
FT   CHAIN        <1   >134       Estradiol 17-beta-dehydrogenase 8.
FT                                /FTId=PRO_0000054596.
FT   ACT_SITE     51     51       Proton acceptor (By similarity).
FT   BINDING      38     38       Substrate (By similarity).
FT   NON_TER       1      1
FT   NON_TER     134    134
SQ   SEQUENCE   134 AA;  13763 MW;  1D351CCF6D6181FF CRC64;
     DWDKVIAVNL KGTFLVTQAA GQALVSSGCS GSIINISSIV GKVGNMGQTN YAASKAGVIG
     LTQTAARELG RHGIRCNSVL PGFIATPMTQ KVPQKVMNKI TGMIPMGHLG DPEDVADVVA
     FLASEDSGYI TGAS
//