[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1016/S0303-7207(00)00421-4; PubMed=11165027 [NCBI, ExPASy, EBI, Israel, Japan] Husen B., Adamski J., Rune G.M., Einspanier A.; "Mechanisms of estradiol inactivation in primate endometrium."; Mol. Cell. Endocrinol. 171:179-185(2001).

Comments

FUNCTION: Uses estradiol as its preferred substrate.
CATALYTIC ACTIVITY: Estradiol-17-beta + NAD(P)⁺ = estrone + NAD(P)H.
CATALYTIC ACTIVITY: Testosterone + NAD⁺ = androst-4-ene-3,17-dione + NADH.
PATHWAY: Steroid metabolism; estrogen biosynthesis .
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF272012; AAG01114.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

Q93X62; 1EDO. [HSSP ENTRY / PDB]

ModBase

Q9GME3.

Family and domain databases

InterPro

IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410; ADH_short_C2; 1.

Pfam

PF00106; adh_short; 1.
Pfam graphical view of domain structure.

PRINTS

PR00081; GDHRDH.
PR00080; SDRFAMILY.

PROSITE

PS00061; ADH_SHORT; 1.

BLOCKS

Q9GME3.

Phylogenomic databases

HOVERGEN

Q9GME3; -.

Other

ProtoNet

Q9GME3.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Lipid synthesis; NAD; Oxidoreductase; Steroid biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 >134`	`>134`	`Estradiol 17-beta-dehydrogenase 8.`	`PRO_0000054596`
`ACT_SITE`	`51 51`		`Proton acceptor (By similarity).`
`BINDING`	`38 38`		`Substrate (By similarity).`
`NON_TER`	`1 1`
`NON_TER`	`134 134`

Sequence information

Length: 134 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 13763 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 1D351CCF6D6181FF [This is a checksum on the sequence]

        10         20         30         40         50         60 
DWDKVIAVNL KGTFLVTQAA GQALVSSGCS GSIINISSIV GKVGNMGQTN YAASKAGVIG 

        70         80         90        100        110        120 
LTQTAARELG RHGIRCNSVL PGFIATPMTQ KVPQKVMNKI TGMIPMGHLG DPEDVADVVA 

       130 
FLASEDSGYI TGAS

Q9GME3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools