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UniProtKB/Swiss-Prot entry Q9GMC8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CP17A_FELCA
Primary accession number Q9GMC8
Secondary accession numbers None
Integrated into Swiss-Prot on May 10, 2004
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 39)
Name and origin of the protein
Protein name Cytochrome P450 17A1
Synonyms EC 1.14.99.9
CYPXVII
P450-C17
P450c17
Steroid 17-alpha-hydroxylase/17,20 lyase
Gene name
Name: CYP17A1
Synonyms: CYP17
From
Felis silvestris catus (Cat) [TaxID: 9685] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Adrenal gland;
Gilep A.A., Huryeva I.V., Guryev O.L., Usanov S.A., Estabrook R.W.;
"Cloning and heterologous expression of the cDNA encoding the cytochrome P450 steroid 17alpha-hydroxylase/17,20 lyase from cat.";
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF292564; AAG02226.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001009371.1; -.
3D structure databases
HSSP P00179; 1DT6. [HSSP ENTRY / PDB]
ModBase Q9GMC8.
Ontologies
GO
GO:0016020; Cellular component: membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0004508; Molecular function: steroid 17-alpha-monooxygenase activity (inferred from electronic annotation from EC).
GO:0006700; Biological process: C21-steroid hormone biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00463; EP450I.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
BLOCKS Q9GMC8.
ProtoNet Q9GMC8.
Genome annotation databases
GeneID 493967; -.
Phylogenomic databases
HOVERGEN Q9GMC8; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase; Steroidogenesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   508  508     Cytochrome P450 17A1. PRO_0000051929
METAL   442   442        Iron (heme axial ligand) (By similarity). 
Sequence information
Length: 508 AA [This is the length of the unprocessed precursor] Molecular weight: 57625 Da [This is the MW of the unprocessed precursor] CRC64: 413FDC4B90FA90D0 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MWELLVFLLF AVAYFLWPKA KCPGAKYPKS LPSLPLVGSL LFLPRSGHPH KNFFKLQKKY 

        70         80         90        100        110        120 
GPIYSFRLGT KTTVMVGDHQ LAKEVLVKKG KEFSGRPHVV TLDILSDNQK GIAFADHGAS 

       130        140        150        160        170        180 
WQMHRKLALA TFALFKDGDQ RLEKIICREI SLLCDNLAMQ DGQSIDLYLP LFLAVTNIIC 

       190        200        210        220        230        240 
LICFNSSFKN GDPALKIIQN YNEGILKTLG KDNLVDIFPV LKIFPNKTLE KMKNYVKNRD 

       250        260        270        280        290        300 
ELLREILEKH KENFSNDSIT NMLDVLIQAR MNSDNNGAAS DQDSKLLSDK HILTTIGDIF 

       310        320        330        340        350        360 
GAGVETTTSV VRWTVAFLLH HPQLYKKLQE EIDQNIGFSR TPTMSDRNQL ILLEATIREV 

       370        380        390        400        410        420 
LRIRPVAPTL IPHKAIMDSS IGEFAVDKGT NVIINLWALH HNEKEWYRPD QFMPERFLDP 

       430        440        450        460        470        480 
TRSQLISPSL SYLPFGAGPR SCLGESLARQ EVFLFMAWLL QRFDLEVPDD GQLPHLEGNP 

       490        500 
TVVFLIAPFK VKVKVRQAWR EAQAEGST
Q9GMC8 in FASTA format

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