ID   IVD2_SOLTU              Reviewed;         401 AA.
AC   Q9FS87;
DT   25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   04-NOV-2008, entry version 51.
DE   RecName: Full=Isovaleryl-CoA dehydrogenase 2, mitochondrial;
DE            Short=IVD 2;
DE            EC=1.3.99.10;
DE   Flags: Precursor; Fragment;
GN   Name=IVD2;
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae;
OC   Solanum.
OX   NCBI_TaxID=4113;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 18-44, AND SUBCELLULAR
RP   LOCATION.
RC   STRAIN=cv. Bintje; TISSUE=Tuber;
RX   MEDLINE=21153238; PubMed=11231285;
RA   Faivre-Nitschke S.E., Couee I., Vermel M., Grienenberger J.-M.,
RA   Gualberto J.M.;
RT   "Purification, characterization and cloning of isovaleryl-CoA
RT   dehydrogenase from higher plant mitochondria.";
RL   Eur. J. Biochem. 268:1332-1339(2001).
CC   -!- CATALYTIC ACTIVITY: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-
CC       2-enoyl-CoA + reduced acceptor.
CC   -!- COFACTOR: FAD.
CC   -!- PATHWAY: Amino-acid degradation; L-leucine degradation; HMG-CoA
CC       from 3-isovaleryl-CoA: step 1/3.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.
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DR   EMBL; AJ278988; CAC08234.1; -; mRNA.
DR   HSSP; P26440; 1IVH.
DR   IntAct; Q9FS87; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0008470; F:isovaleryl-CoA dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR006091; Acyl-CoA_DHase/Oxase_M.
DR   InterPro; IPR006089; Acyl-CoA_DHase_CS.
DR   InterPro; IPR006092; Acyl-CoA_DHase_N.
DR   InterPro; IPR006090; Acyl-CoA_Oxase/DHase_1.
DR   InterPro; IPR013786; AcylCoA_DH/ox_N.
DR   InterPro; IPR013764; AcylCoA_oxidase/DH_1/2_C.
DR   Gene3D; G3DSA:2.40.110.10; Acyl_CoA_DH/ox_M; 1.
DR   Gene3D; G3DSA:1.10.540.10; AcylCoA_DH/ox_N; 1.
DR   Gene3D; G3DSA:1.20.140.10; AcylCoA_DH_1/2_C; 1.
DR   Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR   Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR   Pfam; PF02771; Acyl-CoA_dh_N; 1.
DR   PROSITE; PS00072; ACYL_COA_DH_1; 1.
DR   PROSITE; PS00073; ACYL_COA_DH_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; FAD; Flavoprotein; Mitochondrion;
KW   Oxidoreductase; Transit peptide.
FT   TRANSIT      <1     17       Mitochondrion.
FT   CHAIN        18    401       Isovaleryl-CoA dehydrogenase 2,
FT                                mitochondrial.
FT                                /FTId=PRO_0000000537.
FT   ACT_SITE    262    262       Proton acceptor (By similarity).
FT   NON_TER       1      1
SQ   SEQUENCE   401 AA;  43970 MW;  789FF67CA3B4995D CRC64;
     SALFRIKNHQ KPQFAAFSTS LLFDDTQKQF KESVAQFAQE NIAPHAEKID RTNYFPQDVN
     LWKLMGDFNL LGITVPEEYG GLGLGYLYHC IAMEEISRAS GSVGLSYGAH TNLCINQLVR
     NGTHEQKQKY LPKLISGEHV GALAMSEPDA GSDVVSMKCK ADRVEGGYVL NGNKMWCTNG
     PTAQTLVVYA KTDVTASSKG ITAFIIEKGM TGFSTAQKLD KLGMRGSDTC ELVFENCFVP
     EENVLGQVGK GVYVLMSGLD LERLVLASGP VGIMQACLDV VLPYVKQREQ FGRPIGEFQF
     VQGKVADMYT SMQSSRSYLY SVARECDSGT INTKDCAGVI LSAAERATQV ALQAIQCLGG
     NGYVNEYPTG RFLRDAKLYE IGAGTSEIRR MIIGRELFKE Q
//