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UniProtKB/Swiss-Prot entry Q9EQL9


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SHRPN_RAT
Primary accession number Q9EQL9
Secondary accession numbers None
Integrated into Swiss-Prot on March 20, 2007
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 35)
Name and origin of the protein
Protein name Sharpin
Synonym Shank-associated RH domain-interacting protein
Gene name
Name: Sharpin
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], SELF-ASSOCIATION, INTERACTION WITH SHANK1, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
STRAIN=Sprague-Dawley;
TISSUE=Brain;
DOI=10.1006/mcne.2000.0940; PubMed=11178875 [NCBI, ExPASy, EBI, Israel, Japan]
Lim S., Sala C., Yoon J., Park S., Kuroda S., Sheng M., Kim E.;
"Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins.";
Mol. Cell. Neurosci. 17:385-397(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Heart;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF203906; AAG43482.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC083553; AAH83553.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_112415.1; -.
UniGene Rn.38393
3D structure databases
ModBase Q9EQL9.
Protein-protein interaction databases
IntAct Q9EQL9; -.
Organism-specific databases
RGD 631353; Sharpin.
Gene expression databases
ArrayExpress Q9EQL9; -.
Ontologies
GO
GO:0042802; Molecular function: identical protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR001876; Znf_RanBP2.
Graphical view of domain structure.
SMART SM00547; ZnF_RBZ; 1.
SMART graphical view of domain structure.
PROSITE PS01358; ZF_RANBP2_1; 1.
PS50199; ZF_RANBP2_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9EQL9.
Genome annotation databases
Ensembl ENSRNOG00000012812; Rattus norvegicus. [Contig view]
GeneID 81859; -.
KEGG rno:81859; -.
Phylogenomic databases
HOVERGEN Q9EQL9; -.
Other
ProtoNet Q9EQL9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Metal-binding; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   381  381     Sharpin. PRO_0000280636
ZN_FING   342   371  30     RanBP2-type. 
REGION   1   177  177     Self-association. 
REGION   172   305  134     Interaction with SHANK1. 
Sequence information
Length: 381 AA [This is the length of the unprocessed precursor] Molecular weight: 40287 Da [This is the MW of the unprocessed precursor] CRC64: 8D9A7D7D23665567 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSPPAGGAAA AADPASPVVL LAVQAAVRLL GAGHEDEAQL RKLQLKADPE RPGRFRLGLL 

        70         80         90        100        110        120 
GIEPGAVSLE WPLESICYTI RGPNQHELQP PPGGPGTFSV HFLNSEEAQQ WAALVRDATA 

       130        140        150        160        170        180 
EGQNGNDSTA PVPTPAMCPT SPPCSSVTPT PKATQPEMDL PQGSGNLKKE ELATHLAQAI 

       190        200        210        220        230        240 
AGGDEKAAAQ VAAILAQHHV ALNVQLLEAW FPRGPIRLQV TVEDATSVLS SSSSAHVSLQ 

       250        260        270        280        290        300 
IHPHCSIAAL QEQVFSEFGF PPAVQRWVIG RCLCMPERSL ASYGVSQDGD PAFLYLLSAP 

       310        320        330        340        350        360 
REVSGHSPQH SKMDRKLGCL FPQSLELPHN LQASSSSLPS PPQPGWSCPS CTFINASNRP 

       370        380 
GCEMCSTQRP CAWDPLTATS T 

Q9EQL9 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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