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UniProtKB/Swiss-Prot entry Q9EQ20


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MMSA_MOUSE
Primary accession number Q9EQ20
Secondary accession numbers Q3TDA2 Q8CIB4
Integrated into Swiss-Prot on February 26, 2008
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 55)
Name and origin of the protein
Protein name Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial [Precursor]
Synonyms MMSDH
Malonate-semialdehyde dehydrogenase [acylating]
EC 1.2.1.27
EC 1.2.1.18
Aldehyde dehydrogenase family 6 member A1
Gene name
Name: Aldh6a1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
Yang B.-Z., Zhang L.-F., Roe C.R., Ding J.-H.;
"Mouse methylmalonate-semialdehyde dehydrogenase (MMSDH) cDNA and gene map.";
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J, and NOD;
TISSUE=Cecum, Kidney, and Spleen;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Liver;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-55; LYS-117 AND LYS-331, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1016/j.molcel.2006.06.026; PubMed=16916647 [NCBI, ExPASy, EBI, Israel, Japan]
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.";
Mol. Cell 23:607-618(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF297860; AAG44988.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK033587; BAC28375.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK147146; BAE27715.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK155814; BAE33445.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK169915; BAE41455.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK170305; BAE41702.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK171581; BAE42539.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK171896; BAE42726.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC033440; AAH33440.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_598803.1; -.
UniGene Mm.247510
3D structure databases
HSSP Q28399; 1O9J. [HSSP ENTRY / PDB]
ModBase Q9EQ20.
Organism-specific databases
MGI MGI:1915077; Aldh6a1.
Gene expression databases
ArrayExpress Q9EQ20; -.
CleanEx MM_ALDH6A1; -.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR010061; MeMal-semiAld_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
PTHR11699:SF27; MMSDH; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01722; MMSDH; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; UNKNOWN_1.
BLOCKS Q9EQ20.
Genome annotation databases
Ensembl ENSMUSG00000021238; Mus musculus. [Contig view]
GeneID 104776; -.
KEGG mmu:104776; -.
Phylogenomic databases
HOVERGEN Q9EQ20; -.
Other
SOURCE Aldh6a1; Mus musculus.
ProtoNet Q9EQ20.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    32  32     Mitochondrion (By similarity). 
CHAIN   33   535  503     Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial. PRO_0000320299
NP_BIND   209   213  5     NAD (Potential). 
NP_BIND   261   266  6     NAD (Potential). 
ACT_SITE   317   317        Nucleophile (By similarity). 
BINDING   417   417        NAD (Potential). 
MOD_RES   55    55        N6-acetyllysine. 
MOD_RES   117   117        N6-acetyllysine. 
MOD_RES   331   331        N6-acetyllysine. 
CONFLICT   55    55        K -> R (in Ref. 2; BAE41702). 
CONFLICT   141   141        G -> C (in Ref. 3; AAH33440). 
CONFLICT   211   211        S -> P (in Ref. 2; BAE41702). 
Sequence information
Length: 535 AA [This is the length of the unprocessed precursor] Molecular weight: 57916 Da [This is the MW of the unprocessed precursor] CRC64: 1EF4ED4C4FE2284D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAAAVAAAAA MRSRILQVSS KVNATWYPAS SFSSSSVPTV KLFIDGKFVE SKSDKWIDIH 

        70         80         90        100        110        120 
NPATNEVVGR VPQSTKAEMD AAVESCKRAF PAWADTSILS RQQVLLRYQQ LIKENLKEIA 

       130        140        150        160        170        180 
RLITLEQGKT LADAEGDVFR GLQVVEHACS VTSLMLGETM PSITKDMDLY SYRLPLGVCA 

       190        200        210        220        230        240 
GIAPFNFPAM IPLWMFPMAM VCGNTFLMKP SERVPGATML LAKLLQDSGA PDGTLNIIHG 

       250        260        270        280        290        300 
QHDAVNFICD HPDIKAISFV GSNQAGEYIF ERGSRNGKRV QANMGAKNHG VVMPDANKEN 

       310        320        330        340        350        360 
TLNQLVGAAF GAAGQRCMAL STAILVGEAK KWLPELVDRA KNLRVNAGDQ PGADLGPLIT 

       370        380        390        400        410        420 
PQAKERVCNL IDSGTKEGAS ILLDGRRIKV KGYENGNFVG PTIISNVKPS MTCYKEEIFG 

       430        440        450        460        470        480 
PVLVVLETET LDEAIKIVND NPYGNGTAIF TTNGATARKY AHMVDVGQVG VNVPIPVPLP 

       490        500        510        520        530 
MFSFTGSRSS FRGDTNFYGK QGIQFYTQLK TITSQWKEED ATLSSPAVVM PTMGR 

Q9EQ20 in FASTA format

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View entry in raw text format (no links)
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