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UniProtKB/Swiss-Prot entry Q9EPT4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CP11A_MESAU
Primary accession number Q9EPT4
Secondary accession numbers None
Integrated into Swiss-Prot on May 4, 2001
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 43)
Name and origin of the protein
Protein name Cytochrome P450 11A1, mitochondrial [Precursor]
Synonyms EC 1.14.15.6
CYPXIA1
Cholesterol side-chain cleavage enzyme
P450(scc)
Cholesterol desmolase
Gene name
Name: CYP11A1
Synonyms: CYP11A
From
Mesocricetus auratus (Golden hamster) [TaxID: 10036] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Cricetidae; Cricetinae; Mesocricetus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/S0016-6480(02)00003-5; PubMed=12093115 [NCBI, ExPASy, EBI, Israel, Japan]
Vilchis F., Chavez B., Larrea F., Timossi C., Montiel F.;
"The cDNA cloning and tissue expression of the cytochrome P450scc from Syrian hamster (Mesocricetus auratus).";
Gen. Comp. Endocrinol. 126:279-286(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF323965; AAG42320.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P00189; 1SCC. [HSSP ENTRY / PDB]
ModBase Q9EPT4.
Ontologies
GO
GO:0031966; Cellular component: mitochondrial membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0008386; Molecular function: cholesterol monooxygenase (side-chain-cleaving) activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00463; EP450I.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
BLOCKS Q9EPT4.
Phylogenomic databases
HOVERGEN Q9EPT4; -.
Other
ProtoNet Q9EPT4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cholesterol metabolism; Heme; Iron; Lipid metabolism; Membrane; Metal-binding; Mitochondrion; Monooxygenase; Oxidoreductase; Steroid metabolism; Steroidogenesis; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    36  36     Mitochondrion (By similarity). 
CHAIN   37   520  484     Cytochrome P450 11A1, mitochondrial. PRO_0000003586
METAL   458   458        Iron (heme axial ligand) (By similarity). 
Sequence information
Length: 520 AA [This is the length of the unprocessed precursor] Molecular weight: 60271 Da [This is the MW of the unprocessed precursor] CRC64: 648C5A82D0D41D1E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLAKGLSLRS VLAKGCQPFL SPTWQSSVLA TGGGANISTN SPRPFNEIPS PGDNGWLNLY 

        70         80         90        100        110        120 
HFWRENGTHR IHYHHMQNFQ KYGPIYREKL GNKDSVYILD PEDAAQLFLS EGPYPERYLV 

       130        140        150        160        170        180 
PPWVAYHQYY KRPIGVLFKS SEAWKKDRLV LNQEVMAPEA IKNFVPLLEG VVQDFINVLH 

       190        200        210        220        230        240 
RRIKQQKSGN FSGDISDDLF RFAFESITSV VFGERLGMLE EIVDPESQRF IDAIYQMFHT 

       250        260        270        280        290        300 
SVPMLNLPPE LFRFFRTKTW KEHAAAWDMI FKKADDYTQT FYWDLRQKQE FSKYPGVLYS 

       310        320        330        340        350        360 
LLGGNKLPFK NIQANITEML AGGVDTTSMT LQWSLYEMAH NLKVQEMLRA EVLAARRQAQ 

       370        380        390        400        410        420 
GDMVKMVQLV PLLKASIKET LRLHPISVTV QRYLVDDLVL RNYRIPAKML VQVANYAMGR 

       430        440        450        460        470        480 
EPSFFPNPNK FDPTRWLEKS KNTTHFRYLS FGWGVRQCLG RRIAELEMTI FLINVLENFR 

       490        500        510        520 
IELQSLHDVG TKFNLILMPE KPILFNLQPL KKDLGTTTNR
Q9EPT4 in FASTA format

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