ID   SOX_MOUSE               Reviewed;         390 AA.
AC   Q9D826; O55223;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   04-NOV-2008, entry version 57.
DE   RecName: Full=Peroxisomal sarcosine oxidase;
DE            Short=PSO;
DE            EC=1.5.3.1;
DE            EC=1.5.3.7;
DE   AltName: Full=L-pipecolate oxidase;
DE   AltName: Full=L-pipecolic acid oxidase;
GN   Name=Pipox; Synonyms=Pso;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   MEDLINE=98110586; PubMed=9441754; DOI=10.1006/geno.1997.5050;
RA   Herbst R., Barton J.L., Nicklin M.J.H.;
RT   "A mammalian homolog of the bacterial monomeric sarcosine oxidases
RT   maps to mouse chromosome 11, close to Cryba1.";
RL   Genomics 46:480-482(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Small intestine;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Metabolizes sarcosine, L-pipecolic acid and L-proline
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: Sarcosine + H(2)O + O(2) = glycine +
CC       formaldehyde + H(2)O(2).
CC   -!- CATALYTIC ACTIVITY: L-pipecolate + O(2) = 2,3,4,5-
CC       tetrahydropyridine-2-carboxylate + H(2)O(2).
CC   -!- COFACTOR: Binds 1 FAD per subunit.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Peroxisome (By similarity).
CC   -!- TISSUE SPECIFICITY: Kidney and liver.
CC   -!- SIMILARITY: Belongs to the MSOX/MTOX family.
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DR   EMBL; U94700; AAC39948.1; -; mRNA.
DR   EMBL; AK008555; BAB25741.1; -; mRNA.
DR   EMBL; BC013525; AAH13525.1; -; mRNA.
DR   RefSeq; NP_032978.2; -.
DR   UniGene; Mm.8543; -.
DR   HSSP; P40859; 1EL5.
DR   Ensembl; ENSMUSG00000017453; Mus musculus.
DR   GeneID; 19193; -.
DR   KEGG; mmu:19193; -.
DR   MGI; MGI:1197006; Pipox.
DR   HOGENOM; Q9D826; -.
DR   HOVERGEN; Q9D826; -.
DR   NextBio; 295904; -.
DR   ArrayExpress; Q9D826; -.
DR   CleanEx; MM_PIPOX; -.
DR   GermOnline; ENSMUSG00000017453; Mus musculus.
DR   GO; GO:0005777; C:peroxisome; IDA:HGNC.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR006281; SoxA_mon.
DR   Pfam; PF01266; DAO; 1.
DR   TIGRFAMs; TIGR01377; soxA_mon; 1.
PE   2: Evidence at transcript level;
KW   FAD; Flavoprotein; Oxidoreductase; Peroxisome.
FT   CHAIN         1    390       Peroxisomal sarcosine oxidase.
FT                                /FTId=PRO_0000213774.
FT   NP_BIND       9     39       FAD (Potential).
FT   MOTIF       388    390       Microbody targeting signal (Potential).
FT   MOD_RES     319    319       S-8alpha-FAD cysteine (Probable).
FT   CONFLICT    164    164       Q -> H (in Ref. 1; AAC39948).
FT   CONFLICT    333    333       C -> W (in Ref. 1; AAC39948).
FT   CONFLICT    352    352       K -> T (in Ref. 1; AAC39948).
SQ   SEQUENCE   390 AA;  43847 MW;  0C33A96A24731EE0 CRC64;
     MAAQTDFWDA IVIGAGIQGC FTAYHLAKHS KSVLLLEQFF LPHSRGSSHG QSRIIRKAYP
     EDFYTMMMKE CYQTWAQLER EAGTQLHRQT ELLLLGTKEN PGLKTIQATL SRQGIDHEYL
     SSVDLKQRFP NIRFTRGEVG LLDKTGGVLY ADKALRALQH IICQLGGTVC DGEKVVEIRP
     GLPVTVKTTL KSYQANSLVI TAGPWTNRLL HPLGIELPLQ TLRINVCYWR EKVPGSYGVS
     QAFPCILGLD LAPHHIYGLP ASEYPGLMKI CYHHGDNVDP EERDCPKTFS DIQDVQILCH
     FVRDHLPGLR AEPDIMERCM YTNTPDEHFI LDCHPKYDNI VIGAGFSGHG FKLAPVVGKI
     LYELSMKLPP SYDLAPFRMS RFSTLSKAHL
//