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UniProtKB/Swiss-Prot entry Q9D6R2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH3A_MOUSE
Primary accession number Q9D6R2
Secondary accession numbers Q3UAM8 Q8C8A1 Q9D1L1
Integrated into Swiss-Prot on July 5, 2005
Sequence was last modified on June 1, 2001 (Sequence version 1)
Annotations were last modified on    September 23, 2008 (Entry version 61)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial [Precursor]
Synonyms EC 1.1.1.41
Isocitric dehydrogenase
NAD(+)-specific ICDH
Gene name
Name: Idh3a
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
STRAIN=C57BL/6J, and DBA/2;
TISSUE=Bone marrow, Heart, Tongue, Visual cortex, and Wolffian duct;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
STRAIN=FVB/N;
TISSUE=Liver;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PROTEIN SEQUENCE OF 59-85; 101-115; 135-188; 206-214 AND 300-336, AND MASS SPECTROMETRY.
STRAIN=C57BL/6;
TISSUE=Brain;
Lubec G., Kang S.U.;
Submitted (APR-2007) to UniProtKB.
[4]
PROTEIN SEQUENCE OF 101-169 AND 179-188, AND MASS SPECTROMETRY.
TISSUE=Brain, and Hippocampus;
Lubec G., Klug S., Yang J.W., Zigmond M.;
Submitted (JUL-2007) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK003393; BAB22760.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK010065; BAB26679.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK032787; BAC28021.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK047951; BAC33199.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK150618; BAE29708.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK151304; BAE30286.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK152353; BAE31145.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK153459; BAE32011.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK158646; BAE34596.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK159051; BAE34785.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK168049; BAE40031.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK168149; BAE40114.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK169152; BAE40931.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC034273; AAH34273.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC049956; AAH49956.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_083849.1; -.
UniGene Mm.279195
3D structure databases
HSSP P08200; 1ISO. [HSSP ENTRY / PDB]
ModBase Q9D6R2.
Protein-protein interaction databases
IntAct Q9D6R2; -.
2D gel databases
REPRODUCTION-2DPAGE Q9D6R2; -.
Organism-specific databases
MGI MGI:1915084; Idh3a.
Gene expression databases
CleanEx MM_IDH3A; -.
GermOnline ENSMUSG00000032279; Mus musculus.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR004434; IsoCit_DHase_NAD_mit.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00175; mito_nad_idh; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q9D6R2.
Genome annotation databases
Ensembl ENSMUSG00000032279; Mus musculus. [Contig view]
GeneID 67834; -.
KEGG mmu:67834; -.
NMPDR fig|10090.3.peg.20219; -.
Phylogenomic databases
HOGENOM Q9D6R2; -.
HOVERGEN Q9D6R2; -.
Other
SOURCE Idh3a; Mus musculus.
ProtoNet Q9D6R2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Direct protein sequencing; Magnesium; Manganese; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Transit peptide; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    27  27     Mitochondrion (By similarity). 
CHAIN   28   366  339     Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial. PRO_0000014438
METAL   233   233        Magnesium or manganese (By similarity). 
METAL   257   257        Magnesium or manganese (By similarity). 
METAL   261   261        Magnesium or manganese (By similarity). 
BINDING   115   115        Substrate (By similarity). 
BINDING   125   125        Substrate (By similarity). 
BINDING   146   146        Substrate (By similarity). 
BINDING   233   233        Substrate (By similarity). 
SITE   153   153  1     Critical for catalysis (By similarity). 
SITE   200   200  1     Critical for catalysis (By similarity). 
VAR_SEQ   1    78        Missing (in isoform 2). VSP_014517
CONFLICT   306   306        A -> T (in Ref. 1; BAC33199). 
Sequence information
Length: 366 AA [This is the length of the unprocessed precursor] Molecular weight: 39639 Da [This is the MW of the unprocessed precursor] CRC64: 9F1D68C269376955 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAGSAWVSKV SRLLGAFHNT KQVTRGFAGG VQTVTLIPGD GIGPEISASV MKIFDAAKAP 

        70         80         90        100        110        120 
IQWEERNVTA IQGPGGKWMI PPEAKESMDK NKMGLKGPLK TPIAAGHPSM NLLLRKTFDL 

       130        140        150        160        170        180 
YANVRPCVSI EGYKTPYTDV NIVTIRENTE GEYSGIEHVI VDGVVQSIKL ITEEASKRIA 

       190        200        210        220        230        240 
EFAFEYARNN HRSNVTAVHK ANIMRMSDGL FLQKCREVAE NCKDIKFNEM YLDTVCLNMV 

       250        260        270        280        290        300 
QDPSQFDVLV MPNLYGDILS DLCAGLIGGL GVTPSGNIGA NGVAIFESVH GTAPDIAGKD 

       310        320        330        340        350        360 
MANPTALLLS AVMMLRHMGL FDHAAKIEAA CFATIKDGKS LTKDLGGNAK CSDFTEEICR 


RVKDLD 

Q9D6R2 in FASTA format

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