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UniProtKB/Swiss-Prot entry Q9CGM7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_LACLA
Primary accession number Q9CGM7
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 2003
Sequence was last modified on February 1, 2003 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 45)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: LL1069
ORFNames: L81189
From
Lactococcus lactis subsp. lactis (Streptococcus lactis) [TaxID: 1360] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Lactococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=IL1403;
DOI=10.1101/gr.GR-1697R; PubMed=11337471 [NCBI, ExPASy, EBI, Israel, Japan]
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.;
"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403.";
Genome Res. 11:731-753(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE006339; AAK05167.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E86758; E86758.
RefSeq NP_267225.1; -.
3D structure databases
HSSP P81006; 1GKR. [HSSP ENTRY / PDB]
ModBase Q9CGM7.
Enzyme and pathway databases
BioCyc LLAC272623:L81189-MON; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; 1.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS Q9CGM7.
ProtoNet Q9CGM7.
Genome annotation databases
GeneID 1114709; -.
GenomeReviews AE005176_GR; LL1069.
KEGG lla:L81189; -.
NMPDR fig|272623.1.peg.1101; -.
Phylogenomic databases
HOGENOM Q9CGM7; -.
Genome annotation databases
CMR Q9CGM7; LL1069.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   423  423     Dihydroorotase. PRO_0000147235
METAL   60    60        Zinc 1 (By similarity). 
METAL   62    62        Zinc 1 (By similarity). 
METAL   178   178        Zinc 2 (By similarity). 
METAL   231   231        Zinc 2 (By similarity). 
METAL   304   304        Zinc 1 (By similarity). 
Sequence information
Length: 423 AA [This is the length of the unprocessed precursor] Molecular weight: 45676 Da [This is the MW of the unprocessed precursor] CRC64: 0A0A9CB6749E9B83 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTLLIKNGRL VDPKSNRDEV LDILIENDKI VKIGLNLSVE NAEIVDARGL VVAPGLIDVH 

        70         80         90        100        110        120 
VHFREPGQTH KETIHSGAKS AAAGGFTRVV MMANTKPILS TPKVLTETLE IADKEDIKID 

       130        140        150        160        170        180 
AVGSITQDFD GEHLTDFDEL IKAGAIGFSD DGIPLTDAGV LRKALQKAKL TDSLISIHEE 

       190        200        210        220        230        240 
DPNLIGTLGV NDGEVAHKCG FTGAPTVSEY SMMARDSMIA YETGARLHIQ HLSAGESVEV 

       250        260        270        280        290        300 
VRFAKNLGAK ITAEVTPQHF SITEQMIFEQ GTNAKLNPPL RSTTDIGKII EGLKDGTIDV 

       310        320        330        340        350        360 
IATDHAPHTR EEKNVSLDKA PSGMIGLETS LQLGLTNLVA KGHLTLSELL TKMTVNPAKL 

       370        380        390        400        410        420 
YNFDAGYLAE NGPADLVIFD AENDYQVGET FDSKATNSPF IKQKVQGQVK YTICDGKIVY 


QAK
Q9CGM7 in FASTA format

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