ID   DHOM_LACLA              Reviewed;         428 AA.
AC   Q9CGD8;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   04-NOV-2008, entry version 50.
DE   RecName: Full=Homoserine dehydrogenase;
DE            Short=HDH;
DE            EC=1.1.1.3;
GN   Name=hom; OrderedLocusNames=LL1159; ORFNames=L0090;
OS   Lactococcus lactis subsp. lactis (Streptococcus lactis).
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Lactococcus.
OX   NCBI_TaxID=1360;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   MEDLINE=21235186; PubMed=11337471; DOI=10.1101/gr.GR-1697R;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K.,
RA   Weissenbach J., Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- CATALYTIC ACTIVITY: L-homoserine + NAD(P)(+) = L-aspartate 4-
CC       semialdehyde + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC   -!- SIMILARITY: Contains 1 ACT domain.
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DR   EMBL; AE006348; AAK05257.1; -; Genomic_DNA.
DR   PIR; G86769; G86769.
DR   RefSeq; NP_267315.1; -.
DR   GeneID; 1114801; -.
DR   GenomeReviews; AE005176_GR; LL1159.
DR   KEGG; lla:L0090; -.
DR   NMPDR; fig|272623.1.peg.1193; -.
DR   HOGENOM; Q9CGD8; -.
DR   BioCyc; LLAC272623:L0090-MON; -.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002912; ACT_bd.
DR   InterPro; IPR005106; Asp/hSer_DHase_NAD-bd.
DR   InterPro; IPR016204; hSer_DHase.
DR   InterPro; IPR001342; hSer_DHase_cat.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Complete proteome; Isoleucine biosynthesis; Methionine biosynthesis;
KW   NADP; Oxidoreductase; Threonine biosynthesis.
FT   CHAIN         1    428       Homoserine dehydrogenase.
FT                                /FTId=PRO_0000066696.
FT   DOMAIN      350    423       ACT.
FT   NP_BIND       8     15       NADP (By similarity).
FT   ACT_SITE    206    206       Proton donor (Potential).
FT   BINDING     106    106       NADP (By similarity).
FT   BINDING     191    191       Substrate (By similarity).
SQ   SEQUENCE   428 AA;  46921 MW;  B99C159FB1BEF21C CRC64;
     MTVNIAILGF GTVGTGLPTL ISENKEKLSK ILDEEIVISK VLMRDEKAIE KARAQGYQYD
     FVLTLEEILA DSEISIVVEL MGRIEPAKTY ITKVIKAGKN VVTANKDLLA VHGTELRALA
     EKHHVALYYE AAVAGGIPIL RTLANSFSSD KITHLLGILN GTSNFMMTKM SEEAWTYDQS
     LAKAQELGYA ESDPTNDVDG IDASYKLAIL SEFAFGMTLS PDQISKSGLR TIQKTDVEIA
     QQFGYVLKLT GEINEVESGI FAEVSPTFLP KSHPLASVNG VMNAVFIESD GIGDSMFYGA
     GAGQKPTATS VLADIVRIVK REKDGTIGKS FNEYARPTSL ANPHDIVNKY YFSVETPDST
     GQLLRLVELF TSEDVSFEQV LQQKGDGHRA VVVIISHQIN RVQLLAIQDK LKEEVDFKLL
     NYFKVLGD
//