NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=IL1403;
DOI=10.1101/gr.GR-1697R; PubMed=11337471 [NCBI, ExPASy, EBI, Israel, Japan]
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.;
"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403.";
Genome Res. 11:731-753(2001).

Comments

FUNCTION: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide + H₂O = peptide-L-methionine (S)-S-oxide + thioredoxin.
CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H₂O = L-methionine (S)-S-oxide + thioredoxin.
SIMILARITY: Belongs to the msrA Met sulfoxide reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE006386; AAK05651.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A86819; A86819.

RefSeq

NP_267709.1; -.

3D structure databases

HSSP

P54149; 1FVG. [HSSP ENTRY / PDB]

ModBase

Q9CFC8.

Enzyme and pathway databases

BioCyc

LLAC272623:L193644-MON; -.

Ontologies

GO:0008113;	Molecular function: peptide-methionine-(S)-S-oxide reductase activity (inferred from electronic annotation from HAMAP).
GO:0006464;	Biological process: protein modification process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01401; -; 1.
PBIL [Tree]

InterPro

IPR002569; MsrA.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.1060.10; MsrA; 1.

Pfam

PF01625; PMSR; 1.
Pfam graphical view of domain structure.

ProDom

PD003489; PMSR; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR00401; msrA; 1.

BLOCKS

Q9CFC8.

Genome annotation databases

1115212; -.

AE005176_GR; LL1553.

lla:L193644; -.

fig|272623.1.peg.1595; -.

Phylogenomic databases

HOGENOM

Q9CFC8; -.

Genome annotation databases

CMR

Q9CFC8; LL1553.

Other

ProtoNet

Q9CFC8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 183`	`183`	`Peptide methionine sulfoxide reductase msrA 1.`	`PRO_0000138551`
`ACT_SITE`	`12 12`		`By similarity.`

Sequence information

Length: 183 AA [This is the length of the unprocessed precursor]

Molecular weight: 21331 Da [This is the MW of the unprocessed precursor]

CRC64: D052F9F74B0E04F4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSTERAIFAG GCFWCMVEPF EERPGILAVT SGYTGGHIEY PTYDQVLSKA SGHTEAVEIL 

        70         80         90        100        110        120 
FDNELISYDE LLDIYWSLID PTDADGQIYD RGANYRPVIF VESEEQRIAA QKSKIALEKS 

       130        140        150        160        170        180 
GIWDKPIVVP IEEAKTFWPA EEYHQQYYKK DPKRYQAMHK ARERYLALQR FKGKFKFLRK 


NTR

Q9CFC8 in FASTA format

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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools