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UniProtKB/Swiss-Prot entry Q9C4Z4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ACDA2_METTE
Primary accession number Q9C4Z4
Secondary accession numbers None
Integrated into Swiss-Prot on November 21, 2003
Sequence was last modified on June 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 39)
Name and origin of the protein
Protein name Acetyl-CoA decarbonylase/synthase complex subunit alpha 2
Synonyms ACDS complex subunit alpha 2
EC 1.2.99.2
ACDS complex carbon monoxide dehydrogenase 2
ACDS CODH 2
Gene name
Name: cdhA2
From
Methanosarcina thermophila [TaxID: 2210] 
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=DSM 1825 / TM-1;
DOI=10.1074/jbc.M210484200; PubMed=12464601 [NCBI, ExPASy, EBI, Israel, Japan]
Gencic S., Grahame D.A.;
"Nickel in subunit beta of the acetyl-CoA decarbonylase/synthase multienzyme complex in methanogens. Catalytic properties and evidence for a binuclear Ni-Ni site.";
J. Biol. Chem. 278:6101-6110(2003).
[2]
 ELECTRON MICROSCOPY OF ALPHA-EPSILON COMPLEX.
DOI=10.1006/jsbi.1999.4163; PubMed=10600570 [NCBI, ExPASy, EBI, Israel, Japan]
Kocsis E., Kessel M., DeMoll E., Grahame D.A.;
"Structure of the Ni/Fe-S protein subcomponent of the acetyl-CoA decarbonylase/synthase complex from Methanosarcina thermophila at 26-A resolution.";
J. Struct. Biol. 128:165-174(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF173830; AAG53710.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
ModBase Q9C4Z4.
Ontologies
GO
GO:0018492; Molecular function: carbon-monoxide dehydrogenase (acceptor) activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01137; -; 1.
PBIL [Tree]
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR004460; CO_DHase/Ac-CoA_synth_asu.
IPR016101; CO_DHase_a-bundle.
IPR004137; Prismane.
IPR016099; Prismane-like_a/b-sand.
Graphical view of domain structure.
Gene3D G3DSA:1.20.1270.30; CO_DH_a-bundle; 1.
G3DSA:3.40.50.2030; Prismane-like_a/b-sand; 2.
Pfam PF00037; Fer4; 2.
PF03063; Prismane; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00314; cdhA; 1.
PROSITE PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 2.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9C4Z4.
Other
ProtoNet Q9C4Z4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Iron; Iron-sulfur; Metal-binding; Methanogenesis; Nickel; Oxidoreductase; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   803  803     Acetyl-CoA decarbonylase/synthase complex subunit alpha 2. PRO_0000155084
DOMAIN   405   433  29     4Fe-4S ferredoxin-type 1. 
DOMAIN   443   472  30     4Fe-4S ferredoxin-type 2. 
METAL   72    72        Iron-sulfur 1 (4Fe-4S) (shared with dimeric partner) (By similarity). 
METAL   75    75        Iron-sulfur 1 (4Fe-4S) (shared with dimeric partner) (By similarity). 
METAL   76    76        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   78    78        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   83    83        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   93    93        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   249   249        Nickel-iron-sulfur (By similarity). 
METAL   277   277        Nickel-iron-sulfur (By similarity). 
METAL   322   322        Nickel-iron-sulfur (By similarity). 
METAL   414   414        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   417   417        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   420   420        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   424   424        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   452   452        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   455   455        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   458   458        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   462   462        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   520   520        Nickel-iron-sulfur (By similarity). 
METAL   549   549        Nickel-iron-sulfur (By similarity). 
METAL   584   584        Nickel-iron-sulfur (By similarity). 
Sequence information
Length: 803 AA [This is the length of the unprocessed precursor] Molecular weight: 87738 Da [This is the MW of the unprocessed precursor] CRC64: 1C9565D8E1EAEC14 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAKLTTGSFS IEDLESVQIT INNIVGAAKE AAEKAEEELG PMGPTPFPTA ATVRDWSFTL 

        70         80         90        100        110        120 
FDRYEPVYTP MCDQCCYCTF GPCNLEGNRR GACGLDMKGQ AAREFFLRCI TGCACHSAHG 

       130        140        150        160        170        180 
RHLLDHIISI FGEDMPINMG ASNVIAPNIQ LITGRQPKTL GDLKPIMEYV EEELGQLLAT 

       190        200        210        220        230        240 
VHAGQEGAAI DYDNKAMLAG ILDHVGMEVS DIAQVTALGF PKSDPEAPLV EVGMGTLDAS 

       250        260        270        280        290        300 
KPVIIAIGHN VAGVTYIMDY MEDNNLTDKM EIGGLCCTAF DMTRYKREDR KPPYAKIVGT 

       310        320        330        340        350        360 
ISKELKVVRS GIPDVIVIDE QCVRADLVEE GKKLKIPVIA SNEKVMYGLP DRTNDDVDAI 

       370        380        390        400        410        420 
IEDIKTGKIP GCVMLDYEKL GELVPRLAME MAPLREGISA IPSDEEMASL VAKCVACGEC 

       430        440        450        460        470        480 
ALACPEELDI PDAIQAAKEG DFTALDFLHD LCVGCRRCEQ VCNKEIPILS VIDKAAQKAI 

       490        500        510        520        530        540 
AEEKGLVRAG RGQVSDAEIR AEGLNLVMGT TPGVIAIIGC ANYPAGSKDV YRIAEEFLNR 

       550        560        570        580        590        600 
NYIVAVSGCS AMDIGMYKDA DGKTLYERFP GRFERGNILN TGSCVSNSHI SGTCHKVAAI 

       610        620        630        640        650        660 
FAGRNLSGNL AEIADYTLNR VGAVGLAWGA YSQKAAAIGT GCNMYGIPAV LGPHSGKYRR 

       670        680        690        700        710        720 
ALIAKTYDEN KWKVYDSRNG SELDIPPSPE FLITTAETWQ EACVLLAKNC IRPSDNNMGR 

       730        740        750        760        770        780 
SIKLTHWIEL SEKYLGVLPE DWWKFVRHEA DLPLSRREEL LKKLETEHGW EIDWKKKKII 

       790        800 
SGPKIKFDVS SQPTNLKRLC KEA
Q9C4Z4 in FASTA format

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