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UniProtKB/Swiss-Prot entry Q9BE24

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDHA_MACFA
Primary accession number Q9BE24
Secondary accession numbers Q4R5M9 Q60HF1
Integrated into Swiss-Prot on November 16, 2001
Sequence was last modified on January 23, 2007 (Sequence version 4)
Annotations were last modified on    July 22, 2008 (Entry version 51)
Name and origin of the protein
Protein name L-lactate dehydrogenase A chain
Synonyms LDH-A
EC 1.1.1.27
LDH muscle subunit
LDH-M
Gene name
Name: LDHA
ORFNames: QccE-13024, QccE-13248, QflA-14835
From
Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) [TaxID: 9541] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Frontal cortex;
Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.;
"Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain cortex;
Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.;
"Isolation and characterization of cDNA for macaque neurological disease genes.";
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain cortex;
International consortium for macaque cDNA sequencing and analysis;
"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications.";
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB060222; BAB41156.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB125176; BAD51964.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB169514; BAE01596.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P00338; 1I10. [HSSP ENTRY / PDB]
SMR Q9BE24; 2-332.
ModBase Q9BE24.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS Q9BE24.
Phylogenomic databases
HOVERGEN Q9BE24; -.
Other
ProtoNet Q9BE24.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Cytoplasm; Glycolysis; NAD; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   332  331     L-lactate dehydrogenase A chain. PRO_0000168412
NP_BIND   29    57  29     NAD (By similarity). 
ACT_SITE   193   193        Proton acceptor (By similarity). 
BINDING   99    99        NAD (By similarity). 
BINDING   106   106        Substrate (By similarity). 
BINDING   138   138        NAD or substrate (By similarity). 
BINDING   169   169        Substrate (By similarity). 
BINDING   248   248        Substrate (By similarity). 
MOD_RES   2     2        N-acetylalanine (By similarity). 
MOD_RES   239   239        Phosphotyrosine (By similarity). 
CONFLICT   70    70        L -> F (in Ref. 1; BAB41156). 
Sequence information
Length: 332 AA [This is the length of the unprocessed precursor] Molecular weight: 36632 Da [This is the MW of the unprocessed precursor] CRC64: 70FB912E7A6A7DA5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MATLKDQLIH NLLKEEQTPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVIEDKLKG 

        70         80         90        100        110        120 
EMMDLQHGSL FLRTPKIVSG KDYSVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI 

       130        140        150        160        170        180 
VPNVVKYSPN CKLLIVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV 

       190        200        210        220        230        240 
HPLSCHGWVL GEHGDSSVPV WSGMNVAGVS LKTLHPDLGT DKDKEQWKEV HKQVVESAYE 

       250        260        270        280        290        300 
VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPVSTMIKGL YGIKDDVFLS VPCILGQNGI 

       310        320        330 
SDLVKVTLTP EEEARLKKSA DTLWGIQKEL QF
Q9BE24 in FASTA format

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