[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1016/S0378-1119(96)00480-5; PubMed=8973314 [NCBI, ExPASy, EBI, Israel, Japan] Yaver D.S., Golightly E.J.; "Cloning and characterization of three laccase genes from the white-rot basidiomycete Trametes villosa: genomic organization of the laccase gene family."; Gene 181:95-102(1996).
[2]	SEQUENCE REVISION. Yaver D.S., Golightly E.J.; Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Lignin degradation and detoxification of lignin-derived products (Probable).
CATALYTIC ACTIVITY: 4 benzenediol + O₂ = 4 benzosemiquinone + 2 H₂O.
COFACTOR: Binds 4 copper ions per monomer (By similarity).
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the multicopper oxidase family.
SIMILARITY: Contains 3 plastocyanin-like domains.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L78078; AAB47735.2; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

JC5357; JC5357.

3D structure databases

HSSP

Q96UT7; 1KYA. [HSSP ENTRY / PDB]

ModBase

Q99056.

Ontologies

GO:0008471;	Molecular function: laccase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR001117; Cu-oxidase.
IPR011706; Cu-oxidase_2.
IPR011707; Cu-oxidase_3.
IPR002355; Cu_oxidase_Cu_BS.
IPR008972; Cupredoxin.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.420; Cupredoxin; 3.

Pfam

PF00394; Cu-oxidase; 1.
PF07731; Cu-oxidase_2; 1.
PF07732; Cu-oxidase_3; 1.
Pfam graphical view of domain structure.

PROSITE

PS00079; MULTICOPPER_OXIDASE1; 1.
PS00080; MULTICOPPER_OXIDASE2; FALSE_NEG.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Copper; Glycoprotein; Lignin degradation; Metal-binding; Oxidoreductase; Repeat; Secreted; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 23`	`23`	`Potential.`
`CHAIN`	`24 527`	`504`	`Laccase-5.`	`PRO_0000002947`
`DOMAIN`	`25 150`	`126`	`Plastocyanin-like 1.`
`DOMAIN`	`162 306`	`145`	`Plastocyanin-like 2.`
`DOMAIN`	`373 498`	`126`	`Plastocyanin-like 3.`
`METAL`	`87 87`		`Copper 1 (type 2) (By similarity).`
`METAL`	`89 89`		`Copper 2 (type 3) (By similarity).`
`METAL`	`132 132`		`Copper 2 (type 3) (By similarity).`
`METAL`	`134 134`		`Copper 3 (type 3) (By similarity).`
`METAL`	`425 425`		`Copper 4 (type 1) (By similarity).`
`METAL`	`428 428`		`Copper 1 (type 2) (By similarity).`
`METAL`	`430 430`		`Copper 3 (type 3) (By similarity).`
`METAL`	`480 480`		`Copper 3 (type 3) (By similarity).`
`METAL`	`481 481`		`Copper 4 (type 1) (By similarity).`
`METAL`	`482 482`		`Copper 2 (type 3) (By similarity).`
`METAL`	`486 486`		`Copper 4 (type 1) (By similarity).`
`CARBOHYD`	`74 74`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`77 77`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`156 156`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`209 209`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`233 233`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`242 242`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`276 276`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`317 317`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`358 358`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`366 366`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`393 393`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`402 402`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`464 464`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 527 AA [This is the length of the unprocessed precursor]

Molecular weight: 56247 Da [This is the MW of the unprocessed precursor]

CRC64: F1BE638D65FFA478 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGKYHSFVNV VALSLSLSGR VFGAIGPVTD LTISNADVTP DGITRAAVLA GGVFPGPLIT 

        70         80         90        100        110        120 
GNKGDEFQIN VIDNLTNETM LKSTTIHWHG IFQAGTNWAD GAAFVNQCPI ATGNSFLYDF 

       130        140        150        160        170        180 
TVPDQAGTFW YHSHLSTQYC DGLRGPLVVY DPDDPNASLY DVDDDTTVIT LADWYHTAAK 

       190        200        210        220        230        240 
LGPAFPAGPD SVLINGLGRF SGDGGGATNL TVITVTQGKR YRFRLVSISC DPNFTFSIDG 

       250        260        270        280        290        300 
HNMTIIEVDG VNHEALDVDS IQIFAGQRYS FILNANQSID NYWIRAIPNT GTTDTTGGVN 

       310        320        330        340        350        360 
SAILRYDTAE DIEPTTNATT SVIPLTETDL VPLDNPAAPG DPQVGGVDLA MSLDFSFNGS 

       370        380        390        400        410        420 
NFFINNETFV PPTVPVLLQI LSGAQDAASL LPNGSVYTLP SNSTIEISFP IITTDGVLNA 

       430        440        450        460        470        480 
PGAPHPFHLH GHTFSVVRSA GSSTFNYANP VRRDTVSTGN SGDNVTIRFT TDNPGPWFLH 

       490        500        510        520 
CHIDFHLEAG FAIVWGEDTA DTASANPVPT AWSDLCPTYD ALDSSDL

Q99056 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools