NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Muscle;
DOI=10.1016/S0378-1119(01)00746-6; PubMed=11722846 [NCBI, ExPASy, EBI, Israel, Japan]
Liao C.-H., Ho W.-Z., Huang H.-W., Kuo C.-H., Lee S.-C., Li S.S.-L.;
"Lactate dehydrogenase genes of caiman and Chinese soft-shelled turtle, with emphasis on the molecular phylogenetics and evolution of reptiles.";
Gene 279:63-67(2001).

Comments

CATALYTIC ACTIVITY: (S)-lactate + NAD⁺ = pyruvate + NADH.
PATHWAY: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1 .
SUBUNIT: Homotetramer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the LDH/MDH superfamily. LDH family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF363792; AAK37570.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P00339; 9LDT. [HSSP ENTRY / PDB]

SMR

Q98SL2; 2-332.

ModBase

Q98SL2.

Family and domain databases

InterPro

IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000102; Lac_mal_DH; 1.

TIGRFAMs

TIGR01771; L-LDH-NAD; 1.

PROSITE

PS00064; L_LDH; 1.

BLOCKS

Q98SL2.

Phylogenomic databases

HOVERGEN

Q98SL2; -.

Other

ProtoNet

Q98SL2.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Glycolysis; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 332`	`331`	`L-lactate dehydrogenase A chain.`	`PRO_0000168423`
`NP_BIND`	`29 57`	`29`	`NAD (By similarity).`
`ACT_SITE`	`193 193`		`Proton acceptor (By similarity).`
`BINDING`	`99 99`		`NAD (By similarity).`
`BINDING`	`106 106`		`Substrate (By similarity).`
`BINDING`	`138 138`		`NAD or substrate (By similarity).`
`BINDING`	`169 169`		`Substrate (By similarity).`
`BINDING`	`248 248`		`Substrate (By similarity).`

Sequence information

Length: 332 AA [This is the length of the unprocessed precursor]

Molecular weight: 36722 Da [This is the MW of the unprocessed precursor]

CRC64: DACBE194F94F4EDB [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSVKEHLIHN VHKEEHGHAH NKITVVGVGA VGMACAISIL MKDLADELAL VDVVEDKLRG 

        70         80         90        100        110        120 
EMLDLQHGSL FLRTPKIVSG KDYSVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI 

       130        140        150        160        170        180 
IPNVVKHSPD CKLLVVSNPV DILTYVAWKI SGFPKHRVIG SGCNLDSARF RYLMGERLGI 

       190        200        210        220        230        240 
HPLSCHGWIV GEHGDSSVPV WSGVNVAGVS LKALHPELGT DADKEHWKEV HKEVVDSAYE 

       250        260        270        280        290        300 
VIKLKGYTSW AIGLSVADLA ETVMKNLRRV HPISTMVKGM YGIKDDVFLS VPCVLGYHGI 

       310        320        330 
TDVVMMTLKS EEEEKIRKSA DTLWGIQKEL QF

Q98SL2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools