FUNCTION: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide + H₂O = peptide-L-methionine (S)-S-oxide + thioredoxin.
CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H₂O = L-methionine (S)-S-oxide + thioredoxin.
SIMILARITY: Belongs to the msrA Met sulfoxide reductase family.

Copyright

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Cross-references

Sequence databases

EMBL

BA000012; BAB51164.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_105378.1; -.

3D structure databases

HSSP

P27110; 1FF3. [HSSP ENTRY / PDB]

ModBase

Q98DV6.

Ontologies

GO:0008113;	Molecular function: peptide-methionine-(S)-S-oxide reductase activity (inferred from electronic annotation from HAMAP).
GO:0006464;	Biological process: protein modification process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01401; -; 1.
PBIL [Tree]

InterPro

IPR002569; MsrA.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.1060.10; MsrA; 1.

Pfam

PF01625; PMSR; 1.
Pfam graphical view of domain structure.

ProDom

PD003489; PMSR; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR00401; msrA; 1.

BLOCKS

Q98DV6.

Genome annotation databases

GeneID

1228039; -.

GenomeReviews

BA000012_GR; mll4530.

KEGG

mlo:mll4530; -.

NMPDR

fig|266835.1.peg.3482; -.

Phylogenomic databases

HOGENOM

Q98DV6; -.

Genome annotation databases

CMR

Q98DV6; mll4530.

Other

ProtoNet

Q98DV6.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 195`	`195`	`Peptide methionine sulfoxide reductase msrA 2.`	`PRO_0000138572`
`ACT_SITE`	`18 18`		`By similarity.`

Sequence information

Length: 195 AA [This is the length of the unprocessed precursor]

Molecular weight: 21351 Da [This is the MW of the unprocessed precursor]

CRC64: 9E1BAD9D7A4A2638 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDEKAAPGSE TAIFAGGCFW GVQGVFQHVK GVSKAVSGYT GGAKDDAVYE TVGTGRTGHA 

        70         80         90        100        110        120 
ESVEITYDPS KVTYGQLLQV YFSVAHNPTQ LNFQGPDSGT QYRSTIFAEN DTQKQIAQSY 

       130        140        150        160        170        180 
IDQLDKAKLY PAPIVTTIET GKTFYPAENY HQDFLTLNPT YPYIVYNDLP KVANLKQLFP 

       190 
ALYSEKPVLV LSASN

Q98DV6 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools