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UniProtKB/Swiss-Prot entry Q988P7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX2_RHILO
Primary accession number Q988P7
Secondary accession numbers None
Integrated into Swiss-Prot on March 25, 2003
Sequence was last modified on October 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 38)
Name and origin of the protein
Protein name Histidinol dehydrogenase 2
Synonyms HDH 2
EC 1.1.1.23
Gene name
Name: hisD2
OrderedLocusNames: mlr6649
From
Rhizobium loti (Mesorhizobium loti) [TaxID: 381] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Phyllobacteriaceae; Mesorhizobium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MAFF303099;
DOI=10.1093/dnares/7.6.331; PubMed=11214968 [NCBI, ExPASy, EBI, Israel, Japan]
Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S., Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S.;
"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti.";
DNA Res. 7:331-338(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000012; BAB52900.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_107114.1; -.
3D structure databases
HSSP P06988; 1K75. [HSSP ENTRY / PDB]
ModBase Q988P7.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; atypical; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q988P7.
Genome annotation databases
GeneID 1229769; -.
GenomeReviews BA000012_GR; mlr6649.
KEGG mlo:mlr6649; -.
NMPDR fig|266835.1.peg.5215; -.
Phylogenomic databases
HOGENOM Q988P7; -.
Genome annotation databases
CMR Q988P7; mlr6649.
Other
ProtoNet Q988P7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   500  500     Histidinol dehydrogenase 2. PRO_0000135830
ACT_SITE   381   381        Proton acceptor (By similarity). 
ACT_SITE   382   382        Proton acceptor (By similarity). 
METAL   313   313        Zinc (By similarity). 
METAL   316   316        Zinc (By similarity). 
METAL   415   415        Zinc (By similarity). 
METAL   475   475        Zinc (By similarity). 
BINDING   184   184        NAD (By similarity). 
BINDING   245   245        NAD (By similarity). 
BINDING   268   268        NAD (By similarity). 
BINDING   291   291        Substrate (By similarity). 
BINDING   313   313        Substrate (By similarity). 
BINDING   316   316        Substrate (By similarity). 
BINDING   382   382        Substrate (By similarity). 
BINDING   415   415        Substrate (By similarity). 
BINDING   470   470        Substrate (By similarity). 
BINDING   475   475        Substrate (By similarity). 
Sequence information
Length: 500 AA [This is the length of the unprocessed precursor] Molecular weight: 54015 Da [This is the MW of the unprocessed precursor] CRC64: 71446C53BBF5D9F4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPPAGGIFHR PPTTRKSRRL TPRSACSNST CSRTWGEQPW LLALHSIDSD RNAGRRPCKR 

        70         80         90        100        110        120 
RAIAMIRTIK SARGSVVNGG NGAMTSAVQT LLDQVEQGGD RAVRELSIRF DKFDRDSYRL 

       130        140        150        160        170        180 
TKAEIDACIN SLTGREREDL DFAQDQIRNF AEAQRATLLD LEIETLPGVV LGHRNVPIQN 

       190        200        210        220        230        240 
VGCYVPGGKY PLLASAHMTV LTARVAGCER IITCAPPFQG KVAEKIVAAQ ALAGADEIYC 

       250        260        270        280        290        300 
LGGVQAIAAM AYGTETIAPV DMVAGPGNAY VAEAKRLLFG KVGIDLFAGP TETLVIADDS 

       310        320        330        340        350        360 
VDGELVATDL LGQAEHGVNS PAVLITNSEK LALDTVAEIG RLLTILPTAA IAAKAWEDFG 

       370        380        390        400        410        420 
EIILCETTKE MVAEADRLAS EHVQVMTRDP DHFLNSMRNY GALFLGARTN VSFGDKVIGT 

       430        440        450        460        470        480 
NHTLPTNKAA RYTGGLWVGK FLKTCTYQRI LTDEASALIG EYGSRLSLME GFVGHAEQSN 

       490        500 
IRVRRYGGRN VGYAMPVDPR
Q988P7 in FASTA format

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